FREE
SHIPPING!

on all orders above $300.00

FREE Pills!

VIAGRA PILLS

for free with every order

OUR DRUG PRICES are

70%

Less than in your
local pharmacy

Search by letter:

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Enter coupon: (if you have one)

Cefobid (Cefpodoxime)
+ BONUS
 
Cefpodoxime

Cefobid is an antibiotic and treats infection. Finish taking all of your medication. Even if you feel better, do not stop taking medication unless your doctor tells you to stop. Cefobid is a prescription medication used to treat certain infections of the ears, skin, throat, and urinary tract. It is used to treat pneumonia, sinusitis, and bronchitis. It is also used to treat gonorrhea. Cefobid belongs to a group of drugs called cephalosporins. These work to kill bacteria by preventing them from forming a cell wall. This medication comes as a tablet and liquid to take by mouth and is usually taken twice a day.

Other names for this medication:
Cefpodoxime, Vantin, Cefirax, Cefobid, Cefodox, Cefoprox, Cefpodoxim, Cefpodoxima, Cepodem, Orelox, Otreon, Podomexef, Starpod, Tambac, Victorin,

Similar Products:
Pantosec, Globaxol, Agrixal, Esonix, Redomex, Histaloc, Lamotrix, Synclar, Combivir, Nexcital, Estocin, Rantec, Abilitat, Gimalxina, Kilox, Amimox, Allerfex, Ibarin, Limpidex, Teranex, Lagatrim, Entizol, Bicalutamida, Rozamet, Buspar, Amorion, Gaudium, Omezzol, Emetiral, Efloran, Serenil, Ezol, Clarimax, Omnic, Impril, Ospamox, Eryn, Topra, Trisul, Anafranil, Metrozol, Senexon, Omapro, Disulfiram, Lafigin, Methoxasol, Nortrilen, Tagremin,

cefobid pfizer patient

These results emphasize the importance of lighting conditions and wavelengths during early development for the ontogeny of daily rhythms of gene expression and how these rhythms are reflected on the behavioural rhythmicity of zebrafish larvae. In this work, we reported a new hybrid material (CMC-HA) containing HA drown in a carboxymethylcellulose (CMC)-based hydrogel.

cefobid 1gm is how many mg

There was no overall increase of Fe in barley plants from nZVI-treated soils. A serological probe of cytomegalic infection in southwestern Romania. A child with night blindness: preventing serious symptoms of Refsum disease. Placing more animals at doses close to the targeted BMD provided an estimate of BMD that was slightly better than the standard design with equally sized dose groups.

cefobid renal dose adjustments

The role of sports in making sense of the process of growing old. Reflections about the relationship of a pediatrician in a large clinic to the parents of patients and to pediatric nurses A dipole localization method in analyzing the auditory brain-stem evoked potential Efficacy of Vitamin B6 in Lithium-Associated Tremor: A Case Series.

cefobid pfizer animal health

It is often an advantage to retarget virus infectivity to achieve selective target cell infection. Cellular proliferation at the site of organ allografts and the influence of immunosuppressive therapy. It is probably a general basement membrane-associated glycoprotein because we found material immunologically cross-reactive with the muscle glycoprotein in basement membrane regions of kidney, liver, brain, and small intestine.

cefobid injection

Crystals with smaller size or lower lattice energy have shown to exhibit higher bioavailability with faster rate of release. The chromosomal damage of the peripheral lymphocytes in 459 workers occupationally exposed to benzene and 88 non-exposed controls were detected with cytokinesis-block micronucleus (CBMN) assay. Observations on different skin reactions in pregnancy following intracutaneous injection of androgens, and the relation to the sex of the fetus In contrast to the complete polyoma virus genome, the 244 bp DNA fragment will be particularly useful as a component of mammalian expression vectors since it almost exclusively yielded high levels of correct beta-globin gene transcripts. Behavioral health homes provide primary care health services to patients with serious mental illness treated in community mental health settings.

cefobid uses

The number of atretic follicles started to increase in rats older than 18 months, which corresponded to the cessation of estrous cyclicity. Electronic standardization of chemotherapy forms should be adopted as a best-practice model in hematology-oncology practices throughout the country. Expression of LRP1B was analyzed by quantitative RT-PCR (qRT-PCR) using primers specific for human LRP1B or mouse Lrp1b. Subcutaneous fat necrosis of the newborn and hypercalcemia: case report and review of the literature.

cefobid pfizer inc

Principles: mechanisms and modeling of synergism in cellular responses. Comparison of Tl-201 chloride and Ga-67 citrate scintigraphy in the diagnosis of thyroid tumor: concise communication. A reduction in postoperative corticosteroid substitution and a return to almost physiological function on discontinuation of long-term substitution can be achieved. However, little is known about claudin partners for transport mechanisms and membrane organization. Racial Variation in Patient-Reported Outcomes Following Treatment for Localized Prostate Cancer: Results from the CEASAR Study.

cefobid action

Perinatal lipid nutrition alters early intestinal development and programs the response to experimental colitis in young adult rats. No bone reconstructions were conducted in all patients with the bone defects of skull base. In contrast to other enveloped viruses with such a binding specificity (influenza viruses and paramyxoviruses) IBV lacks a receptor-destroying enzyme.

cefobid dosage index

This clearly shows a difference in the documentation of the Ottawa ankle rules by the health practitioners questioning whether appropriate care is given. These results demonstrate the feasibility of screening large pools of L. Eosinophil infiltration and degranulation in tissues from 52 patients with the TOS were examined by immunofluorescence staining for the eosinophil granule major basic protein (MBP). Three cases are described in which there was concurrent development of acute cholecystitis and a second acute abdominal illness. The use of a medial or an extended medial gastrocnemius flap appears to be a reliable option for reconstruction of a ruptured extensor mechanism after TKA.

cefobid renal dose for dopamine

Included in the study were Medicare beneficiaries dying with poor-prognosis cancer from 2003 to 2007. Pawpaw extract was prepared by pulp extraction with methanol and liquid-liquid partitioning with ethyl acetate (EtOAc). Serological surveillance reveals widespread influenza A H7 and H9 subtypes among chicken flocks in Egypt. Some survey responses indicated a correlation with additional teaching time.

cefobid dosage index

Effect of TGF-beta 1, TGF-beta 2, and bFGF on chick cartilage and muscle cell differentiation. These results suggest that the lesion of the guanine nucleotide regulating components coupled to the catalytic moiety of the enzyme complex is a crucial factor in the desensitization of catecholamine-sensitive adenylate cyclase and the preservation of enzyme reaction could be accomplished by agents increasing intracellular calcium, which in turn, maintain the nucleotide regulatory components coupling to the cyclase in a protective environment from desensitization. A systematic internet and literature search up to February 2015 was carried out.

cefobid flagyl dosage

The judicial inprisonment procedure in hospitalization of psychic patients and drug addicts To evaluate the efficacy of combination therapy of argon laser photocoagulation and intravitreal antivascular endothelial growth factor (VEGF) injection in idiopathic polypoidal choroidal vasculopathy (PCV) involving macula.

cefobid injection mold

Clustering of similar peptides around regions of high sequence identity and known bioactivity was also observed. These results suggest that proMMP-9, which binds to a receptor complex containing TIMP-1 and ADAM10, is activated by the MT1-MMP/MMP-2 axis, and MMP-9 thus activated stimulates cellular proteolysis and metastasis.

cefobid iv

  • cefobid injection
  • cefobid renal dose augmentin
  • cefobid renal dose zosyn
  • cefobid injection sites
  • cefobid dose
  • cefobid iv
  • cefobid cost
  • cefobid uses
  • cefobid dosage index
  • cefobid pediatric dose
  • cefobid renal dose amoxicillin
  • cefobid dosage of aspirin
  • cefobid flagyl uses
  • cefobid pfizer
  • cefobid flagyl dose
  • cefobid renal dose dobutamine
  • cefobid antibiotic
  • cefobid pfizer connection
  • cefobid pfizer news
  • cefobid 1gm is how many mg
  • cefobid renal dose levaquin
  • cefobid injection for osteoporosis
  • cefobid renal dose xarelto
  • cefobid renal dose adjustments
  • cefobid renal dose cipro
  • cefobid paediatric dose augmentin
  • cefobid paediatric dose of paracetamol
  • cefobid dosage of benadryl
  • cefobid flagyl antibiotic used to treat
  • cefobid injections
  • cefobid generic name
  • cefobid dosage calculation
  • cefobid flagyl medication
  • cefobid renal dose of dopamine
  • cefobid side effects
  • cefobid flagyl for uti
  • cefobid coverage one insurance
  • cefobid renal dose dopamine
  • cefobid renal dose vancomycin
  • cefobid dosage
  • cefobid injection molding
  • cefobid renal dose adjustment
  • cefobid injection site
  • cefobid in pregnancy
  • cefobid pfizer patient
  • cefobid dosage for benadryl
  • cefobid dosage calculations
  • cefobid medscape general medicine
  • cefobid pfizer logo
  • cefobid dosage calculator
  • cefobid pfizer inc
  • cefobid pfizer animal health
  • cefobid paediatric dose of ceftriaxone
  • cefobid medscape drug
  • cefobid dosage of tylenol
  • cefobid dosage for infant
  • cefobid renal dose of zosyn
  • cefobid renal dose for dopamine
  • cefobid pfizer allergan
  • cefobid renal dose medications
  • cefobid indications of pregnancy
  • cefobid renal dose ciprofloxacin
  • cefobid paediatric dose

cefobid dosage

The same receptor binds both LDL and apo-E HDLc, but the apo-E HDLc bind with much higher affinity. All tooth implants which were either not put under strain or were immediately put under pressure healed without reaction. Clinicopathologic values at admission were compared to test the use of SAA and haptoglobin concentrations in predicting euthanasia, complications, and hospitalization duration and cost.

cefobid renal dose for dopamine

We further show that dendritic calcium spikes arising during REM sleep are important for pruning and strengthening new spines. Evidence for APOBEC3B mRNA and protein expression in oral squamous cell carcinomas.

cefobid renal dose adjustments

The performance of graduates of foreign medical schools was lower than those of our last year medical students in four of the eight stations of the examination. In Group Two 6 months after surgery, of 46 cases, the stent ceased to function in 8 patients.

cefobid paediatric dose for azithromycin

Animal models have played, and still play, a substantial role in understanding the patho-physiology and treatment of human epilepsies. Therefore, in addition to its documented role in LG delivery to the plasma membrane, Rab27a may restrict LG movement in the cytosol. Controlled synthesis of racemic indenyl rare-earth metal complexes via the cooperation between the intramolecular coordination of donor atoms and a bridge. Gingerol and shogaol exhibited potent molluscicidal activity on Biomphalaria glabrata. Conventional protein microarray substrates often suffer from non-specific protein adsorption and inhomogeneous spot morphology.

cefobid injection mold

Single alanine substitution mutations at Asp-450 or Asp-467 of the type IIS restriction enzyme Fok I have no effect on the ability of the enzyme to bind strongly and selectively to its recognition site but completely eliminate its ability to cleave either strand of substrate DNA. Early components of averaged evoked responses to rapidly repeated auditory stimuli. This often leads to the misidentification of harmless objects as weapons held by a Black individual. Besides visual validation, quantitative evaluations demonstrate that our single-scale fusion (SSF) strategy is able to yield results that are highly competitive with traditional multiscale fusion (MSF) approaches.

cefobid renal dose dopamine

Further, a novel thiol-elimination method for preparation of the mc-APD group is outlined. A single observer performed slice-by-slice manual segmentation using a digital high resolution screen. Bacterial and phage GT6 genes influence the surface chemistry of bacteria, affecting their interactions, including those with vertebrate hosts. Significant improvements were observed in the psychosocial and spiritual dimensions assessed.

cefobid 500 ml

Active arteriovenous leakage as determined by simple physical examination is all-important in determining the outcome of these lesions. Hexamethonium, a peripheral nicotinic antagonist, strongly potentiated aggressiveness. Liver and eye have previously been shown to be effective matrices for the detection of residual concentrations of the drug. Outputfrom the Mesoscale Meteorological Model (MM5) employed with observational nudging was used in both models.

cefobid medscape general medicine

Inhibitory effects of aminoglutethimide and isoxazole on progesterone production and deciduoma formation in rats. Kinematic models of the upper limb joints for multibody kinematics optimisation: An overview.

cefobid uses

hualiensis occurred across oceanographic features that are typically barriers to small, pelagic fish dispersal. There is a need for additional research in this area, especially regarding the use of alternative measures to physical restraints. Especially in resource poor setting health care workers are managing huge number of HIV infected patients that made them to be more exposed to HIV infection. Lactate was observed within the infarcted region in two patients at 9 and 11 days after infarction and may have been present in other patients up to 15 weeks after stroke.

cefobid renal dose levaquin

Here, using the actin cytoskeletal networks as an example, we will provide snapshots of current advances in defining the structures of these highly dynamic networks in situ. When fibroblasts were cultured on the PMBV surface, the cells adhered and proliferated normally while showing a spherical morphology. The analysis using deletion-mutated Par14 and IRS-1 constructs revealed the N-terminal portion containing the basic domain of Par14 and the two relatively C-terminal portions of IRS-1 to be involved in these associations, in contrast to the WW domain of Pin1 and the SAIN domain of IRS-1. FtsZ is widely conserved in photosynthetic eukaryotes, where it forms a ring inside the organelle at the chloroplast division site. Hydrocortisone sodium succinate (HSS) was sequentially encapsulated in Amberlite 717 and Eudragit S100 to prepare the HSS-loaded resin microcapsule (HSS-DRM).

cefobid cost

Limited value of PCNA immunohistometry on tru-cut biopsies in inflammatory and cirrhotic liver disease. Development of Guidelines for Health Impact Assessment in Southern Italy. However, the high-resolution images of large object areas and different fields of view obtained by 3D reconstruction make one wonder whether it can add a new insight into lung adenocarcinoma, the most frequent histology type of lung cancer characterized by its morphological heterogeneity. Renal TOD included creatinine, glomerular filtration and albumin/creatinine ratio. These receptors are not solubilized by detergent, show saturable binding, and yield linear Scatchard plots of the type associated with a single class of binding sites of high affinity.

cefobid generation names

Cloning, sequencing, and expression of the pantothenate kinase (coaA) gene of Escherichia coli. The treatment of Pseudomonas keratitis has many limitations, and further investigation to identify more effective approaches is required.

cefobid flagyl for uti

If we assume that the development of expertise is a long-term phenomenon, then it follows that future research can engage in advanced statistical modelling of longitudinal expertise data that extends the routine use of cross-sectional material through, for example, animations and dynamic visualisations of developmental data. To cure these patients, a more radical operation and/or effective adjuvant treatment is needed. The limits of detection of the heptafluorobutyryl derivatives of mexiletine and of its metabolite are 20 and 7 ng/ml of plasma, respectively.

cefobid dosage of pepto

A total of 231 patients from a randomized phase 3 trial with American Joint Committee on Cancer/International Union Against Cancer stage III to stage IVB NPC (except T3-T4N0 disease) who were receiving treatment with the TPF regimen were enrolled. To present the first reported series of patients undergoing myopic LASIK with the FEMTO LDV Crystal Line femtosecond laser and the WaveLight Allegretto Eye-Q excimer laser.

cefobid drug

Activation of the HPA axis increased the susceptibility of BALB/c.Bcgs mice to the growth of M. nTMS maps were generated using a repetitive TMS protocol to deliver trains of stimulations during a picture naming task. The electrospray technique is advantageous over other conventional methods as it generates nanomaterials of particle sizes in the micro/nanoscale range. The methodology included basic audiologic evaluation, mismatch negativity (MMN) in response to speech and tone stimuli and memory tests. We describe a patient who presented with a transient ischemic event in whom transesophageal echocardiography showed presence of an accessory lobe within the left atrial appendage that was in atrial fibrillation by pulsed wave Doppler when the left and right atrial appendages, pulmonary vein, and right atria were in sinus rhythm.

cefobid dosage of amoxicillin

Age, race, gender, tumor size, histology, and grade appear to be more important prognostic factors. Although undersampled, this trial shows significantly longer mechanical ventilation with barbiturates and the occurrence of severe treatment-related complications in both arms.

cefobid renal dose bactrim

Thereafter, 10 patients with DM among 27 PM/DM patients developed A/SIP, and they were given combination therapy with PSL, CSA, and IVCYC. Does spironolactone ameliorate trastuzumab-induced cardiac toxicity? The rad52 and rad54 extracts are more impaired in the recombination of plasmids containing double-strand breaks than of intact plasmids, whereas rad50 extracts are deficient equally for both types of substrate. A biphasic magnetic solution containing lithium polysulfide and magnetic nanoparticles is used as catholyte, and lithium metal is used as anode.

cefobid oral dose

High levels of adherence in clinical trials are essential for producing accurate intervention efficacy estimates. Effect of isosorbide dinitrate on the capillaries of the myocardium In parallel, ethanol ingestion blunted the innate immune response of alveolar macrophages during injurious ventilation ex vivo and after endotoxin stimulation in vitro.

cefobid renal dose cipro

Development of the PCR-test system for detection primate betaherpesvirinae One-Year Tuberculosis Risk in Rheumatoid Arthritis Patients Starting Their First Tumor Necrosis Factor Inhibitor Therapy from 2008 to 2012 in Taiwan: A Nationwide Population-Based Cohort Study. The present study is concerned with the question as to whether the acute treatment of intact rats or hepatocytes with glucagon and dibutyryl cAMP, respectively, leads to a stabilization or an activation of mitochondrial functions, such as state-3 respiration, succinate dehydrogenase activity and pyruvate carboxylase activity.

cefobid pfizer pharmaceuticals

Although increased incidences of study disorders were not identified in this population, it is possible that within individual families one or more of these disorders is related to childhood central nervous system tumorigenesis. Effects of cobalt chloride and cycloheximide on the hepatic microsomal enzyme system and biliary excretion rate in control and phenobarbital-pretreated rats. Interrogative visualization--the ability to extract, enumerate, deform and track objects of interest is also crucial in other visualization tasks. Is esophagogastroduodenoscopy necessary in patients with positive fecal occult blood tests and negative colonoscopy? Our data suggest that these new right ventricular leads ECG may be helpful in detecting Brugada syndrome in SUDS survivors and their relatives.

cefobid flagyl dose

Disturbed sleep in children with ADHD: is there a place for melatonin as a treatment option? 3 cases of trisomy 18(trisomy E) found among 10,000 children born alive: typical and atypical forms The resources needed to operate a hematology laboratory are known only as rough approximations. Genes for indoleacetic acid production (iaaM and iaaH) are necessary for gall induction by the olive pathogen Pseudomonas savastanoi. The regions of synteny that were detected provide an important tool for defining and cataloging genes in the QTL regions for advancing chestnut blight resistance research.

cefobid renal dose

Early alterations consist of a loss of elastin followed by a breakdown of the microfibrils and subsequent fragmentation of the elastic fiber. To assess the utilization of sterilizing equipment used by dentists, and verification of sterilization using biological indicators.

cefobid paediatric dose of metronidazole

Heat treatment significantly reduced the creep of all alloy types studied. Oocyte microinjection assay for evaluation of Ras-induced signaling pathways.

Testimonials
Best
 Show Hide 
cefobid pfizer viagra 2010-06-26

RhoGDI2 antagonizes ovarian carcinoma growth, invasion and metastasis. Cellular polypropylene polymer foam as air-coupled ultrasonic transducer materials. Existing animal models often include the release of mediator cascades (sepsis-, lung injury pentalink 40 mg models) or are based on small laboratory animals.

cefobid dosage index 2017-02-02

Flow-diverter stents decrease blood flow into an aneurysm to prevent its rupture. Activity in biclar forte bijsluiter zaldiar motor-sensory projections reveals distributed coding in somatosensation.

cefobid flagyl and alcohol 2017-06-20

Considerable acycloguanosine common name controversy about the value of participating in Maintenance of Certification has recently arisen within the medical community. To introduce an auto-electrocardial counterpulsation device, which is non-invasive, nonmedicative and easy to operate, to patients of pulmonary heart disease. In paraplegic patients, the temperature increase was significantly less than in the normal subjects and there was no significant thermally induced hyperaemia after surface insulation. A macular choroidal volume map and 3-dimensional topography were automatically created by the built-in software of the device. Sitting time was positively associated with the prevalence of NAFLD, and this association might be affected by inflammation.

cefobid flagyl antibiotic 2017-04-30

This case report describes congenital absence of the popliteal artery discovered during operative exploration after a traumatic injury to the lower extremity. There were 24 males and 21 females, ranging in age from 34 to 45 years old. Physicians, Poverty, and Profits: Can augmentin 1 gm doses Robin Hood Finance Health Care in Developing Countries? Electromigration is a slow, linear process, while voltage-sensitive mechanisms respond in a rapid, nonlinear fashion.

cefobid pfizer allergan 2016-05-23

The lethal rates and body weight responses of male Wistar rats following oral treatment with gossypol acetic acid (GAA) at dosages of 2.5-30 mg/kg were analysed by various laroxyl 10 mg etken maddesiresstudio statistical procedures. The adrenergic innervation, which orginates almost entirely from the superior cervical sympathetic ganglia, begins to develop around birth and is fully established 3 weeks later. Multifactorial breast cancer etiology also involves circadian gene alterations, especially among individuals exposed to light at night.

cefobid pfizer logo 2019-11-22

Palmyra is sister to Aphrodita, and both Pisione and Pholoe are positioned within Sigalionidae, suggesting that both family names Pisionidae and Pholoidae should be treated as junior synonyms of Sigalionidae. To our knowledge there is no comparable article concerning the WS in the literature. Compounds II, IV, V were obtained from the fruits of the plant for the first time. To assess the left ventricular diastolic function in patients on haemodialysis. Equivalence regarding both safety and efficacy between budesonide/formoterol Easyhaler and Symbicort Turbuhaler was shown elevation of carbamazepine-10 11-epoxide by quetiapine dosage based on totality of evidence from the PK studies and IVIVC analyses, and therefore, therapeutic equivalence between the products can be concluded.

cefobid pfizer viagra 2010-03-31

Using a novel model, we predicted which microbial production strategies are optimal for economic return, by capturing the tradeoff between the market prices of substrates, product output and the efficiency of microbial production. In metronidazole tabletas 500 mg dosis de amoxicilina general it is not possible to write an analytic expression for the fluorescence signal generated by a fluorophore distributed in a scattering medium such as tissue. For this purpose, we draw on accurate mass spectrometry, selectively labeled standards, and published fragmentation pathways to structurally annotate all dominant mass peaks of a large collection of metabolites, some of which with a complete fragmentation pathway. In the proximal tubule segment the second, ore distal part (PII) reacted, in general, very strongly when compared with the first proximal part (PI). Delimiters applied were humans, English language and years 1990-2007.

cefobid pfizer careers 2016-09-23

PsAKR1- or OsAKRI-expressing tobacco and rice transgenic plants showed improved tolerance to glyphosate with reduced accumulation of shikimic acid without affecting the normal photosynthetic rates. After the surgery, the patient recovered perfectly well and he returned to his pre-injury level of physical activity in two months. metronidazole dose for diarrhea Risk factors for failed vacuum extraction and associated complications in term newborn infants: a population-based cohort study.

cefobid renal dose adjustments 2019-06-30

Superiority of concomitant chemoradiation over sequential chemoradiation in inoperable, locally advanced non-small cell lung cancer: challenges in the selection of appropriate chemotherapy. A pair of viruses isolated from the levitra 10 mg vardenafil same patient differed by eight amino acids, including a Lys/Glu disparity at 627 of PB2, previously identified as an H5N1 virulence factor in mice. In this largest study to date of GH-producing pituitary adenomas in which iMR imaging-guided transsphenoidal surgery was analyzed, the results suggest that this method is a highly effective and safe treatment modality, even compared with previously published surgical series in which high-field iMR imaging was used.

cefobid dosage for infant 2015-12-03

Authors discuss the general aspects of viral infections and the principles of antiviral chemotherapy. Two investigators extracted, assessed and coded separately all pyridostigmine br 60 mg cost data for each study.

cefobid dosage for benadryl 2019-02-17

Southern blot and DNA sequence analysis revealed inter-species DNA polymorphism within the region spanned by primers G1 and G2 between L. The results of this study are particularly important for those working directly and indirectly with bullied youth. Because Drp1 has been shown to be important tablet zosert 100 for apoptosis and necroptosis, it is puzzling how Purkinje neurons die in the absence of Drp1. The aim of this study is to investigate the effect of splenectomy on liver regeneration. Nuclease I from suspension-cultured Nicotiana tabacum: purification and properties of the extracellular enzyme.

cefobid dose 2015-10-03

Based on the molecular data of the mitochondrial cytochrome c oxidase subunit 1 (cox1) gene, A. While it is true that the majority of children with CHD today will survive, many will have prevacid generic lansoprazole impaired neurodevelopmental outcome across a wide spectrum of domains.