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We have used a recently developed in vitro replication system from Staphylococcus aureus to determine the origin and direction of replication of pT181 plasmid DNA. Kinetics of electron transfer between NADPH-cytochrome P450 reductase and cytochrome P450 3A4. Regulation of extracellular alkaline protease activity by histidine in a collagenolytic Vibrio alginolyticus strain. Rapid eye movement sleep behavior disorder in parkinsonism with parkin mutations.

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Intervertebral ligament, which is known to form intervertebral joints in cooperation with the notochord, was severely degenerated by RA, leading to fusion of centra. A noteworthy proportion use suboptimal dosing, and very few choose postdischarge prophylaxis.

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Research has provided limited evidence of associations between illness perceptions, satisfaction with consultations, and medication adherence. Laparoscopic distal gastrectomy with regional lymph node dissection for gastric cancer. Hair digestion and subsequent solid phase extraction or liquid-liquid extraction were described as well as extraction in organic solvents. Epithelioid sarcoma (ES) is a rare malignancy notorious for its tendency to histologically mimic granuloma annulare and other palisading granulomatous processes. Radiographs of three different textures, including computer-stimulated lesions of various sizes and densities, were subtracted from radiographs taken before lesions were placed.

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The carbonate fraction has a distribution suggesting its dissolution during transport. The microvascular complications in the retina and kidneys are preceded and accompanied by functional abnormalities.

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The obtained results indicate that the expression of a proliferation antigen by Ki-67 immunohistochemistry can be used to evaluate the biological behavior of neuroendocrine tumors of the digestive system and predict survival. Pulmonary infection may thus directly induce tumor progression in NSCLC. An investigation into the structural and the functional relationship in centromeric tandem repeats in HACs requires the ability to manipulate repeat substructure efficiently. Plate osteosynthesis at the proximal femur is possible for intertrochanteric and subtrochanteric femoral fractures. The objective of this study is to report the process of implementing the ToC approach in developing mental health care plan.

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It mediates anti-inflammatory effects in particular by inhibiting the release of T helper type 1 (Th1) cytokines. Risk of pacemaker or implantable cardioverter defibrillator after radiotherapy for early-stage breast cancer in Denmark, 1982-2005. Compound C and SB203580 also inhibited glucose uptake induced by OHC-4p and OHC-2m.

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We sought to report on national trends postoperative clinical outcomes for minimally invasive liver and pancreatic surgery. Association of each SNP with different traits was tested with a weighted linear model, using SNP genotype as a covariate and animal as a random variable. There were also no text and opinion pieces that were specific to canine-assisted interventions, long term care settings and older people. Quantitative angiographic characterisation of coronary artery disease in patients with human immunodeficiency virus (HIV) infection undergoing percutaneous coronary intervention.

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Age-related changes in retinal ganglion cell (RGC) activity may impact results of long-term functional studies of disease progression and drug efficacy in humans and animal models. Prolonged breast-feeding (six months or more) and milk fat content at six months are associated with higher developmental scores at one year of age within a breast-fed population. All pregnant occupants in a motor vehicle crash require physician evaluation. Facial postinflammatory hyperpigmentation (PIH) is challenging to manage in patients with skin of color because of the risk of subsequent treatment-related hyperpigmentation.

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Our results suggest that the mixed inocula of OM5 and EM9 strains as biofertilizers could significantly increase the production of food crops in Andaman archipelago by means of sustainable and organic agricultural system. Knowledge of the various appearances of pseudoaneurysms and of the proper management is essential to prevent a catastrophic outcome in cases of pseudoaneurysm. The outcome of conservative treatment for anastomotic leakage after surgical repair of esophageal atresia. Tissue histomorphometric analyses conducted 8 h after administration showed no changes in bone formation or bone resorption parameters. Middiaphyseal radial ostectomy was performed in 2 dogs that had premature closure of their distal radial physes.

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The computational implementation of the elevation angle degree of freedom is considered in a different way than described in the recommendation of the International Society of Biomechanics (ISB). The IAP waveform is modeled as the sum of a spike and a slow repolarization phase. MPA treatment also dampened expression of the costimulatory molecules CD40, CD70, and CD80 by dendritic cells (DC) in lymph nodes draining acute infection, whereas coculture of such DC with T cells from uninfected mice dramatically impaired ex vivo T cell proliferation compared with the use of DC from mice that did not receive MPA prior to HSV-1 infection.

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Rehabilitation of patients with chronic nonspecific lung diseases Doxorubicin-poly (ethylene glycol)-alendronate self-assembled micelles for targeted therapy of bone metastatic cancer. The use of oxybutynin in patients treated by means of botulinum neurotoxin A for neurogenic detrusor overactivity: an observational study. Our data indicate that children with epilepsy due to pathogenic GRIN2A mutations present with different clinical phenotypes and a spectrum of seizure types in the context of a pharmacoresistant epilepsy providing information for clinicians treating children with this form of genetically determined epileptic syndrome.

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These species can react with cellular components (lipids, proteins, nucleic acids) and cause lipid peroxidation, membrane damage and inactivation of enzymes thus affect many physiological processes as well as cell viability. The mRNAs encoding all three activin/inhibin subunits are expressed in breast carcinoma, fibroadenoma, and normal mammary tissue. Forty-nine first-episode, drug-naive schizophrenia patients and 50 age-, sex-, and education-matched healthy controls underwent structural and resting-state functional magnetic resonance imaging (fMRI) scanning.

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Responsibility of dentists with regard to patients entitled to disability insurance benefits This study aimed to examine whether the mode of onset and the duration of coronary spasm influenced progression of organic coronary stenosis and acute myocardial infarction in a swine model of coronary spasm.

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Our study provides compelling evidence that significant disparities exist for CSHCN by primary household language status across all health care quality indicators. These results indicate that SBHA may play antitumor functions via regulating Notch1/p53 signals, and highlight that SBHA could have clinical potential to benefit the therapy of ATC patients. In Vitro, hypoxia induced a significant increase in 661W cell death that paralleled increased activity of JNK and c-jun.

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Continuous measurement of cardiac output with the use of stochastic system identification techniques. Tetracycline regulated ectopic gene expression is a widely used tool to study gene function. The aim of the study is to determine the role of the extract on both apoptotic and autophagic cell death in HeLa cell line.

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In opposite a significant decrease in D2 receptor mRNA expression both after the first dose of methamphetamine and methanandamide (that persisted also after the methamphetamine challenge doses) was registered. The data indicated that adrenal secretions were not responsible for the decrease in plasma PRL induced by blood sampling initiated in the afternoon. Our previous data showed that treatment of rats with a tachykinin NK3R antagonist caused a reduction of litter size.

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Patients were divided into non-late acetabular dysplasia (non-LACD) and late acetabular dysplasia (LACD) groups according to final results and age at reduction, sex and side compared between these two groups. The P/C ratio seems to be highly predictive for diagnosis to detect proteinuria over one gram and it could be used as a rapid alternative test in preeclamptic patients not to delay implementation treatment.

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Clinical transplantation of ex vivo expanded autologous limbal epithelial cells using a culture medium with human serum as single supplement: a retrospective case series. In addition, ELISA also detected significantly higher levels of LCN2 in patients with periodontal disease than in healthy subjects. Characterization of acidification by the isolated perfused rat kidney: evidence for adaptation by the distal nephron to a high bicarbonate diet.

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The advancement of optical methodologies used in cell biology research has given the tools to elucidate cellular mechanisms that would otherwise be impossible to visualize. A clinical and molecular genetics study of primary congenital glaucoma in South Korea. Cre-lox66/lox71-based elimination of phosphotransacetylase or acetaldehyde dehydrogenase shifted carbon flux in acetogen rendering selective overproduction of ethanol or acetate. Priorities for quality care in pediatric oncology supportive care. Gene selective suppression of nonsense termination using antisense agents.

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(5) The observed effect of E2 on mammary tumorigenesis may be due in part to the generation of 16 alpha-OHE1, which functions as a weak initiator or a potent promoter of tumorigenic transformation in mammary epithelial cells. The Beck Depression Inventory (BDI-II) was used to measure depressive symptoms before and after the intervention. The association between per capita consumption of alcohol and the proportion of excessive consumers--a reply to Skog. The need for alcohol intervention programs was expressed by the TB patients, their families and health providers.

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A new infestation by Aedes albopictus was discovered in Civitavecchia, Central Italy, in October 1992. The effect of multiple infections on the reproduction of influenza virus A consistent and significant improvement in the visualization of the injured kidney was noted in the dopamine-treated animals compared with controls that received equivalent volumes of normal saline. Acute trauma patients with elevated preoperative platelet counts are at increased risk for lower extremity free flap complications.

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Thus, by targeting RPA and mimicking DNA, DSS1 functions with BRCA2 in a two-component homologous recombination mediator complex in genome maintenance and tumor suppression. Salivary cortisol was collected 3 times during 3 therapy sessions. Protein-protein interactions (PPIs) play a vital role in the biological processes involved in the cell functions and disease pathways. The impact of day of surgery on the length of stay for major urological procedures.

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Resuscitation training for cardiac patients and their relatives--its effect on anxiety. Redox control of transcription: sensors, response regulators, activators and repressors. We found that human endothelial cells express the multidrug resistance protein-1 (MRP1) and use this as their major exporter of GSSG.

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Neglected tropical diseases and the 2012 US presidential election. Creation of a blood-compatible surface: a novel strategy for suppressing blood activation and coagulation using a nitroxide radical-containing polymer with reactive oxygen species scavenging activity. Previous studies have reported an excellent safety profile and few adverse outcomes with CEW use in adults.

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A low allergen diet is a significant intervention in infantile colic: results of a community-based study. The popularity of phosphodiesterase type 5 (PDE-5) enzyme inhibitors for the treatment of erectile dysfunction has led to the increase in prevalence of illicit sexual performance enhancement products. ASGR is a multifunctional receptor specializing in clearance of desialylated glycoproteins and platelets. The T to R transition in the copper(II)-substituted insulin hexamer.

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More data is required to ascertain whether extra-motor features arise with progression of disease. These results indicate that the level of transferrin receptors may be the major factor which determines the rate of iron uptake during erythroid cell development. The aim of this study was to identify predictors of 30-day mortality in patients with malignant pleural effusion (MPE) who need pleural palliative procedures. The environment plays a role in the bacterial diversity of the microbiota, which could enable the development of new control strategies for mosquito-borne disease. Also no islet cell tumor was found in the pancreas, suggesting the tumor as the site of ectopic insulin production.

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We found that NK-2 showed enhanced killing effect with NP-1 and NP-2 biogenic nanoparticles at a 0.5-ppm concentration, whereas LLKKK-18 showed antibacterial activity only with NP-2 at 0.5-ppm dose against M. Dexamethasone also restored the normal responsiveness of the renin-aldosterone system to postural stimuli.

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It was further demonstrated that linear limitations, if added to the dose in healthy organs and tissues, make the task even more complicated if not insoluble. Accordingly, our microarray data may provide clues for finding novel genes involved in prostate cancer progression to androgen independent and metastasis, and shed light on finding new targets for diagnosis and therapy of prostate cancer.

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Lack of bactericidal effect of antibiotics except aminoglycosides on Bartonella (Rochalimaea) henselae. All patients with scaphoid fractures who were treated in the Orthopaedic Section of Haugesund Hospital from 1987 up to and including 2011 were included in the study. There was an increase in energy intake during treatment and the increase in the ingestion of fruits and legumes was associated with significant increases in energy intake.

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Lung transplantation in patients 70 years old or older: have outcomes changed after implementation of the lung allocation score? The inflammatory response demonstrates less inflammation than previously reported with CO(2) laser injury.

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The eCLiPS method provides a new tool to profile the ligand specificity of protease exosites and to develop improved substrates. Nationwide data on urolithiasis were acquired from Health Insurance Review and Assessment Service between 2009 and 2013.

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The goal of this work was to investigate the role of proprioception in modulating hemispheric balance during a short-term right arm immobilization. The endocannabinoid system (ECS) functions to adjust behavior and metabolism according to environmental changes in food availability. The Surveillance Epidemiology and End Results (SEER) database was used to identify patients with MTEC who had undergone esophagectomy from 2004 to 2012. Such an approach to learning disabilities can be expected to be rewarding. The earliest appearance of the arthrospores was seen by scanning electron microscopy as compartments delineated by double ridges.

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The seventh (and last?) International Microbicides Conference: from discovery to delivery. Functional genomic studies revealed that one of these SNPs (rs11849538) created an estrogen response element and that TCL1A expression was estrogen dependent, was associated with the variant SNP genotypes in estradiol-treated lymphoblastoid cells transfected with estrogen receptor alpha and was directly related to interleukin 17 receptor A (IL17RA) expression. This method is compared to a traditional full-volume-fat-only method in phantom and human studies.

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The information collected offers insights into areas where additional support or interventions may be needed and provides baseline information for future public health research in the area of mental illness. A meaningfully inverse association between Bmi-1 and RKIP was found in tissue microarray studies, and was verified further in gastric cancer cell lines. Quality improvement interventions lower the risk of inhospital death in patients with AMI.

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Hemoproteins have been suggested to contribute to various forms of tissue injury by catalyzing the peroxidation of lipids. Results of the study demonstrated a significant frequency and diversity of complications. Word shape, orthographic regularity, and contextual interactions in a reading task. Fracture-dislocation of the humeral condyles in adults: results of surgical treatment.

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A sheared liquid suspension whose flow is reversed remembers with various degrees of perfection all earlier configurations of the particles. The efficacy of these agents was evaluated in patient subgroups with low variability. Chronic necrotizing aspergillosis (semi-invasive form) is described in patients with chronic lung pathology or mild immunodeficiency. Simple Clinical Score to Predict 24-Week Survival Times in Patients with Inoperable Malignant Distal Biliary Obstruction as a Tool for Selecting Palliative Metallic or Plastic Stents.

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General anesthesia causes reduction of functional residual capacity. URO-OVA mice developed profound bladder inflammation with increased mast cell counts and LUTD, including increased total number of voids, decreased mean volume voided per micturition, and decreased maximum volume voided per micturition, after cystitis induction. Impact of a single insulin treatment (imprinting) applied during liver regeneration on hepatic insulin receptor development, blood glucose level and liver function parameters in adult rats. To reduce this pain, we devised a simple method of rib spreading and closure (intercostal bundle-splitting thoracotomy), which avoids the intercostal nerve during thoracotomy, and then verified its effectiveness.

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Prognostic models based on pretreatment clinical and laboratory variables can help identify patients more likely to benefit from standard therapies, as well as assist in the interpretation of drug effectiveness in Phase II clinical trials. Maternal Smoking Status in Successive Pregnancies and Risk of Having a Small for Gestational Age Infant. First admission rates were much higher in France than in England before the age of 45, but lower after that age. These studies suggested that an apoA-I mimetic can improve endothelial healing of arterial injuries by decreasing oxidative stress.

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A comparison of PET A of acute-stage patients with that of healthy controls showed increases in glucose metabolism in the cerebellum, motion-sensitive visual cortex areas, and inferior temporal lobe, but none in vestibular cortex areas. Biosimilars are drugs that are similar, but not identical, to originator biologics. Exome (via NGS) and Sanger sequencing revealed that biallelic sequence variants in a novel gene (HERC1) might be related to the disease pathogenesis. Surprisingly, the magnitude of friction and traction forces is decreasing with slug velocity indicating that these quantities are probably related to the dynamics of cell/substrate adhesion complexes.