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Clofen (Baclofen)
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Baclofen

Clofen is a prescription drug used to relieve muscle spasms, primarily in the treatment of multiple sclerosis or spinal cord diseases. According to the U.S. National Library of Medicine, this medication relieves spasms of the musculoskeletal system, relieves pain, and improves muscle movement. In the past decade, Clofen has been used with increasing frequency in the treatment of drug and alcohol addiction. In this usage, Clofen functions to lessen the symptoms of withdrawal. Prescribing Clofen to treat addiction is still considered an “off-label” use of the medication, or a use outside of what is approved by the FDA, but this use has shown some success in clinical trials, according to a study published by Cochrane Database of Systematic Review.

Other names for this medication:
Baclofen, Lioresal, Baclofene, Baclofeno, Baclon, Baclopar, Barambo, Clofen, Kemstro, Liofen, Lyflex, Miorel, Pacifen,

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This mechanism enables a rapid, tissue-specific response to nutritional changes, tailoring stem cell divisions and egg production to environmental conditions sufficient for progeny survival. The systemic administration and topical administration (in the form of eye drops) of DIZE increased the ACE2 expression in the eyes and significantly decreased the IOP of glaucomatous rats without changing the blood pressure. Taken together, these results suggest that CCK-8 could be involved in behavioral adaptation to situations producing change in emotional and/or motivational states through modulation of presynaptic D2 receptor functioning.

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Papillary fibroelastomas are rare, benign cardiac tumors that are often found on cardiac valvular surfaces. Changes in the phosphorylation state of Stat3 and nuclear factor kappaB were observed due to delayed fixation and reproducibly quantified. Maternal anthropometry, such as low BMI, had effects on placental diameter and weight, which, in turn, adversely affected fetal weight. Kon-tiki enhances PS2 integrin adhesion and localizes its ligand, Thrombospondin, in the myotendinous junction.

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The case histories of two patients presenting to the Royal North Shore Hospital are reviewed. Some suggestions are made from social psychology and genetic counselling about how families can best handle risk information to achieve the goal of neither under- nor overestimating the risks at these different stages of the multiple pregnancy. Among 12 cases invading SVC or brachiocephalic veins, 9 cases during the last 7 years underwent SVC resection and reconstruction with EPTFE grafts. It also noteworthy that historic therapeutic methods are sometimes reintroduced for purposes not envisioned by their original makers. The primary transgene encodes the nuclear tagging fusion protein (NTF), which consists of a nuclear envelope-targeting domain, the green fluorescent protein, and a biotin ligase recognition peptide, while the second transgene encodes the E.

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Many patients are asymptomatic and the lessions are found incidentally. Molecular cloning of the monodehydroascorbate reductase gene from Brassica campestris and analysis of its mRNA level in response to oxidative stress. Patients with heart failure, COPD, renal failure, cancer, functional loss or malnutrition require extra attention on transition from hospital to home in order to lower the number of unnecessary readmissions. Some features of optical scheme arrangement for the polarizing technique are discussed.

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VEGF receptor 2 inhibition resulted in an increase in intratumoral distribution and therapeutic efficacy despite the maturation of the tumor vasculature. Comparison of colony stimulating activities secreted into mouse lung conditioned medium in the presence and absence of lithium chloride. Based on a generalized Volmer isotherm the interfacial phase transition is discussed for the hydrophobic surfactant proteins, SP-B and SP-C, as well as for the mixtures of dipalmitoylphosphatidylcholine (DPPC) with these proteins. The current standard practice is intermittent positive pressure ventilation with positive end-expiratory pressure.

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Randomized prospective trials are needed to evaluate the role of initial definite locoregional treatment in these patients. Insulin at physiologically relevant concentrations promoted glioblastoma cell growth and survival, potentially via Akt activation.

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We analyzed composite indicators created from participant responses using the mean above minus mean below a cut (MAMBAC), Maximum Covariance (MAXCOV), and latent mode factor analysis (L-Mode) taxometric procedures. The mice were tested for mechanical hyperalgesia by determining the nociceptive hind paw withdrawal pressure threshold. In addition to displaying data in an organized manner, computational tools that use the underlying allele frequencies with user-provided data are implemented in FROG-kb. After cardiac transplantation bacterial mediastinitis is a severe early complication.

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International studies have shown that physicians have an elevated risk of developing depression or burnout syndrome. There is evidence to link stress with the onset of major depression and with a poorer prognosis in cardiovascular disease and cancer.

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Here, we demonstrate high-resolution melting analysis (HRMA) as a cost-effective and powerful tool for screening variable target genes in natural populations. Withdrawal of the drug and treatment with systemic steroids and fibrinolytic drugs resulted in improvement of visual acuity to 6/6. Dietary variety was assessed using a 10-item food frequency questionnaire. A retrospective review of a prospectively maintained database of 200 consecutive patients who underwent RPD in a large academic center from October 3, 2008, through March 1, 2014, was evaluated for important metrics of quality.

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These include maintaining an appropriate mixture of air and water in soil, nutrient cycling and carbon sequestration. Effect of functional changes in the dopamine system of the brain on enkephalinamide-induced catalepsy in the rat Patients 65 years and older who had ED fall visits in 2012 and who had primary care physicians within our hospital network during the past 3 years were included. Mitral valve replacement and tricuspid annuloplasty were performed successfully.

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The activity of NF-kappa B activation became stronger at 1 hour in the TNF-alpha stimulated group than the control, peaked at 2 hours and then decreased at 4 hours. Accurate diagnosis and adequate surgical excision are critical in reducing local recurrences and improving outcomes. Hepatic inflammation (grade 0-4) and fibrosis (stage 0-4) for patients were assessed histologically.

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The results obtained by both methods of analysis are in good agreement and indicate that vitellogenin mRNA is present in the liver of normal roosters at a level of 0-5 molecules per liver cell and increases in amount during the 3 days following injection of estrogen, reaching a level of almost 6000 molecules per cell at the peak of the response. Attitudes of employers and employment agencies that may provide short-term contracts to individuals with mental health needs are important to understand if these individuals are to be given access to paid employment.

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HPV-positive women had significantly higher risk of having precursor lesions (of any grade) and cancer compared to HPV-negative women. A total of 610 male students were selected for present cross sectional study and their blood pressure (BP) and body mass index (BMI) was determined, other data was gathered through a questionnaire, and SPSS-16 was used for analyzing data.

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A charge transfer single crystal field effect transistor operating at low voltages. However, when genes in the old rat were compared with those in the old rat treated with KRG, KRG treatment up-regulated C21-steroid hormone metabolism.

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Our primary objective was to survey obstetrics and gynecology (Ob/Gyn) clerkship directors regarding timing and methods for teaching and assessment of pelvic and breast examination skills in United States medical school curricula, and to assess clerkship director satisfaction with current educational strategies at their institutions. Three linked nomograms for predicting biochemical failure in prostate cancer treated with radiotherapy plus androgen deprivation therapy. Analyzing longitudinal leukocyte data from bovines infected with either methicillin-resistant (MRSA) or methicillin-susceptible (MSSA) Staphylococcus aureus, two methods were investigated: (i) an approach that assesses lymphocytes, monocytes, or neutrophils, separately, and (ii) a method that, using dimensionless indicators (products, ratios, or combinations derived from leukocyte data), explores the dynamics of leukocyte relationships in three-dimensional (3D) space and identifies data subsets of informative value. Nitrogen (N) availability is a major factor determining plant growth and productivity. Further studies, including larger study samples and control groups, are needed to corroborate these findings.

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Cells of JM109/pKT901EA induced for tryptophanase synthesized L-tryptophan from indole, ammonia, and pyruvate more efficiently than E. enterocolitica at 25 degrees C completely suppressed its capacity to degrade mucin, suggesting that this activity depends on plasmid expression. The complaint of dyspareunia should be considered during treatment of female patients with BD. In September 1982, the WHO Expert Committee on Biological Standardization adopted the revised model. These results suggest that PAF-acether stimulates PGI2 and TXA2 production in rat dental pulp by interacting with distinct PAF-acether receptors, and that these receptors are coupled to independent signal transduction pathways which have a different dependence on extra- and intracellular calcium.

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We show that CCRET has powerful and robust performance under multiple types of etiological heterogeneity, and has performance comparable to or better than existing methods when there is no heterogeneity. Indeed, the use of a heterogeneous catalyst allows an easy active phase recycling without multi-step recovering while the heterogeneous catalyst used here exhibits high catalytic activity for the reaction considered. In the normal brain, PDE1 is localized in all four principal parts of the brain: cerebrum, diencephalon, brainstem and cerebellum. The findings indicate a high prevalence of tetracycline discolorations and enamel defects but a significantly reduced dental caries experience in these patients. In the chicken pineal gland, the pinopsin mRNA level was significantly more abundant than the others, of which the OPN4-2 mRNA level was higher than that of OPN4-1.

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The development of dependence can pose significant challenges when discontinuation is attempted as withdrawal symptoms often develop. We have proposed a feedback control by NTPs that down-regulates E2F-1. It is essential to document our data regarding the outcomes of elderly patients so that other countries showing similar population aging trends can learn from our experiences. Moderate and severe knee pain, defined from an intensity or discomfort scale (threshold 3 on a 6-level scale in 1994-1995, and 4 on an 8-level scale in 2006), were the main outcomes.

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We have identified and characterized here the regulator CroS as a key factor in the stimulation of conjugative transfer of these ICEs in response to DNA-damaging agents. beta 2-agonists are the most effective bronchodilators and act predominantly on airway smooth muscle.

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Scanning electron micrographs (SEMs) confirmed homeotic sepal-to-carpel transformation in the transgenic plants. Cascading failures in interdependent networks with finite functional components. Several mouse models of accelerated carcinogenesis have gained user confidence and are being applied to product development decision-making. Their easy availability should enable comparisons with local, national and international standards, and may favor quality improvement. Sociodemographic predictors of self-rated health in patients with diabetes of short duration.

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Within the scope of main categories, fifty-nine subcategories were analyzed. Our studies demonstrate that alveolar macrophage function is impaired in patients with CF. Accordingly, the neocortex remained plastic even beyond the peak of its natural critical period. The high cost of care, including that for clotting factor concentrates, makes hemophilia a potential target for cost-cutting efforts by health care payers. Simple surface modifications can enhance coronary stent performance.

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The model is used to simulate the experimental frontal head impact tests using a cylindrical padded impactor. Overall, the results showed no effect of the interventions on mood, quality of life, subjective cognitive impairment or independence. Following rituximab at 0, 1, 6, and 18 months, response was favorable after the second dose, usual life activity resumed after the third dose (uveitis was inactivated and vision improved), and eyes stabilized 9 months after the fourth dose. Abrupt out-of-plane edge folding of a circular thin plate: Implication for a mature Victoria regia leaf.

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To investigate the extent of knowledge of Australian general practitioners (GPs) in terms of critical information about adolescent suicide. AP-1 activity in SW1417 cells expressing activated Ki-ras was higher than that in control cells. It exhibits the beneficial physiological effects of therapeutic and nutritional values akin to dietary fiber. The most technically demanding aspect of the procedure may be placement and drilling of the tibial tunnel.

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A substantial obstacle for the further development of quantum computers is the fact that the lifetime of quantum information is usually too short to allow practical computation. Intriguingly, the altered cross-talk between the components of such a triangle of death, beyond altering the redox homeostasis of the neuron, is further exacerbated by increased levels of OS that target and impair key components of the pathways involved. We identified many cases of emergent metabolism (856 of 3570 possible cases). We investigated the role of vagal innervation for handling of oral and i.v.

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The epidemiology, diagnosis, immune response to, and available therapies for these diseases are discussed. The involvement of RAGE in pathophysiologic processes has been demonstrated in murine models of chronic disease using either a receptor decoy such as soluble RAGE (sRAGE), RAGE neutralizing antibodies, or a dominant-negative form of the receptor. Among the important topics that will be discussed in this review are the following: the role of vascular endothelial dysfunction in microvascular leak, the impact of cytokines upon structural and functional proteins within the endothelial barrier and within the heart, and the ability of selective vasopressin 1a receptor agonists to minimize tissue edema and improve hemodynamic status.

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Although Le Fort I osteotomy superior impaction during bimaxillary surgery is beneficial for patients with a long face, achieving satisfactory results can be challenging due to the redundant upper lip. A case of multiple congenital anomalies including unusual ear nodules and finger contractures: a new genetic syndrome? The Ministry of Health together with AMREF have incorporated a comprehensive intervention system to address the commonly occurring diseases such as malaria, diarrhoea and pneumonia and address adults and children problems differently.

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Recent evidence has suggested that changes within the brain and central nervous system may underlie these functional deficits, with support arising from direct neurophysiologic measures of somatosensory dysfunction, motor system excitability, and plasticity of neural networks. Accidentally crushed stent during complex bifurcation treatment. Future research should seek to understand the underlying mechanisms of the identified predictive factors to improve recurrence prediction and to reduce morbidity and mortality. We report here that the ligation of alpha 2 beta 1 integrin by collagen-adhesion stimulatory anti-alpha 2 and anti-beta 1 antibodies resulted in the accumulation of p21ras in the active GTP-bound state in Jurkat T-lymphoblastoid cells.

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The patient was referred to our hospital for detailed examinations. Survival after recurrence of osteosarcoma: a 20-year experience at a single institution. Data from the OECD Health Statistics and the Better Life Index are reaching policy makers and the public in a manner that potentially distorts professional and political discourse on health.

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Inhibition of emotion-related autonomic arousal by skin pressure. Radiologically controlled drainage of pleural and pulmonary collections. Dust was observed from the 35th day onward only in the reusable oxygen humidifier. The bottom line is that workplaces should be physically, emotionally, and psychologically safe for well-being and healthy behaviors to flourish. We performed a retrospective review of 124 consecutive patients with a total of 151 open ureteral reimplantations for postcystectomy ureteroenteric strictures between January 2006 and December 2015.

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The test and control group underwent esophagogastroduodenoscopy with taking biopsies from the stomach for PCR detection of H. However, many patients are unable to achieve optimum benefits from azathioprine or 6-mercaptopurine because of undesirable metabolism related to high thiopurine methyltransferase (TPMT) activity characterized by hepatic transaminitis secondary to increased 6-methylmercaptopurine (6-MMP) production and reduced levels of therapeutic 6-thioguanine nucleotide (6-TGN). The assay is specific for influenza virus with a sensitivity of detection limit of approximately 10 copies of RNA by PCR. Phosphorylation-independent modulation of L-type calcium channels by magnesium-nucleotide complexes. This longitudinal study used a representative community sample of same-sex twins (485 monozygotic pairs, 271 dizygotic pairs) to study longitudinal changes in genetic and environmental influences on nicotine dependence (NicD) symptoms and major depressive disorder (MDD) symptoms and the longitudinal relationships between NicD and MDD symptoms at three relatively discrete ages spanning middle adolescence to early adulthood (ages 15, 18, and 21).

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The response to kainic acid was assessed by the frequency of wet-dog shakes behavior and limbic seizures. New findings in microbiology and immunology in patients at risk for endotoxic shock. Internal training load was calculated using Banister TRIMP, Edwards TRIMP, individualized TRIMP (iTRIMP), Lucia TRIMP (luTRIMP), and session rating of perceived exertion (sRPE).

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Evident Proptosis and Diplopia Due to Massive Orbital Ivory Osteoma. The pathogenesis of liver fibrosis has evolved dramatically in recent years. The objective of this meta-analysis was to determine the effects of controlled aerobic training on resting HR among sedentary older adults. Evolution of complex resistance transposons from an ancestral mercury transposon.

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Treatment of tibial PCL avulsion fractures by arthroscopic suture fixation is a successful technique to restore tibial avulsion injuries of the PCL with well-documented radiographic healing, good clinical outcomes, and low complication rates. Bottom-up fabrication of graphene on Ru(0001) via molecular self-assembly. Massive neutrophil activation has been proven detrimental in numerous diseases, yet in RSV the contribution of neutrophils to disease severity, and thereby, the relevance of targeting them, is largely unknown.

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Olmesartan and Bay11-7082 inhibit the MCF-7 cells growth indicating RAS and NF-kappaB pathway blockade lead to cytotoxicity and apoptosis induction against tumour cells. Rate of non-intercepted admission MREs identified via a voluntary reporting system. They came to our outpatient clinic complaining of persistent dry cough. Effect of repeated intradermal injections of bovine herpesvirus type 1 antigen on seronegative pantoprazole magnesium nursing implications for zofran cattle. Modulation Index Adjustment for Recovery of Pure Wavelength Modulation Spectroscopy Second Harmonic Signal Waveforms.

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Here we present a familial cluster of Q fever presenting as highly variable synchronous manifestations in four of five family members, including prolonged fever of unknown origin, asymptomatic carrier state, hepatitis, and chronic endocarditis developing in the omeprazole magnesium 40mg absence of previous symptoms. Furthermore, it provides better time-frequency resolution, and is robust to model mismatches. A novel post-translational incorporation of tyrosine into multiple proteins in activated human neutrophils. One step formation of propene from ethene or ethanol through metathesis on nickel ion-loaded silica.

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Electron microscopic analysis revealed that SMC metronidazole gel brown discharge formed multilayers around the outside of the capillaries, whereas EC, subjected to 3 dyn/cm2 shear stress, formed an intact closely adherent monolayer lining the capillary lumen. The proposed co-culture system allowed regulation of the dissolved oxygen concentration at a level suitable for an individual microorganism in each fermentor, as well as the successful exchange of culture medium between two fermentors.

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Gender-specific associations of serum antibody to Porphyromonas gingivalis and inflammatory markers. In an analysis of 80 plasma samples the microarray platform performs well across the range of total PSA levels. Blockage of CD59 Function Restores Activities of Neutralizing and Nonneutralizing Antibodies in Triggering Antibody-Dependent Complement-Mediated Lysis of ivermectina tab 6 mg of xanax HIV-1 Virions and Provirus-Activated Latently Infected Cells. The mucosal immune system: master regulator of bidirectional gut-brain communications. One of twenty arginine residues of this enzyme is concerned with this alteration of activity, as shown by the result of its modification at pH 6.9.

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Type II: This hepatic esomeprazole 20 mg posologia bactrim artery arose from an unusual hepato-mesenteric trunk off the aorta immediately inferior to the gastro-lienal trunk. Recombinant cytosolic mouse isozymes were compared with respect to steady state kinetics, chain length of polyglutamate derivatives formed, and end-product inhibition by the major reduced folylpentaglutamate cofactors. The most frequent lesions found were severe thickening of the atrioventricular node artery, intranodal and perinodal fibrosis, and microscopic foci of chronic inflammatory infiltration. The experimental comparisons have illustrated the satisfactory imaging performance of the proposed method in terms of quantitative and qualitative evaluations. We assessed hospital resource use in children by type and number of LT-CCCs.

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In vitro, the vigora tablet video stand growth and conidiation capacities of the mutants were similar to those of the parental strain. So far, however, an interaction of this type could not be detected in ruminants.

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Seedlings resulting from interpopulation pollinations developed more slowly and were less likely cloridrato de amitriptilina 25 mg engorda de borregos to survive to produce cotyledons than seedlings resulting from all three intrapopulation pollination distances. No evidence that supports involvement of ribonuclease III in initiation of Co1E1 DNA replication or its regulation was found.

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Atrial fibrillation ablation results in functional impairment of the UGI system, including ribavirin dose calculator for dogs the esophagus, stomach, and small intestine. Pretreatment with 35 kDa HA, in contrast, increased smoke-induced neutrophil infiltration and lung injury score.

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Interleukin-8 (IL-8) does not activate NADPH oxidase, but potentiates the oxidative burst induced by stimuli such as formyl-methionyl-leucyl-phenylalanine (fMLP) via a priming mechanism. Escherichia coli deletion mutants lacking DNA topoisomerase I have been identified previously and shown to grow at a normal rate. Does pantoprazole sod dr tabs 40mg an increasing intima media thickness predict the cardiovascular risk?

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Treatment of invasive Aspergillosis in children with hematologic malignancies. Our experience has given us good results with minimal antibiotics for uti bactrim resistance intra- and postoperative complications. Lingual epithelial thickness in mice with inherited iron-deficiency anaemia (sla). This article presents the case report of a female patient with lymphangioleiomyomatosis who underwent single lung transplantation on the left side on 4.

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Levels of c-myc peaked at 2 hours and were sustained for an additional 4 hours before gradually declining. Colocalization of lexinor norfloxacin 400mg tablets low-methylesterified pectins and Pb deposits in the apoplast of aspen roots exposed to lead. The observation is made by measuring the current-voltage characteristics for a fluxon trapped in an annular Josephson junction that was placed into a microwave field. A discrete modeling approach enables the underlying mechanistic rule concerning the basic architecture and dynamics of fungal networks to be studied on the scale of a single colony.