on all orders above $300.00

FREE Pills!


for free with every order



Less than in your
local pharmacy

Search by letter:


Enter coupon: (if you have one)

Hascovir (Acyclovir)

Hascovir is best used as soon as possible after the symptoms of herpes infection or shingles (for example, pain, burning, blisters) begin to appear. If you are taking Hascovir for the treatment of chickenpox, it is best to start taking Hascovir as soon as possible after the first sign of the chickenpox rash, usually within one day. Hascovir capsules, tablets, and oral suspension may be taken with meals or on an empty stomach. Hascovir is best taken with a full glass (8 ounces) of water. If you are using Hascovir oral suspension, use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.

Other names for this medication:
Acyclovir, Abduce, Acic, Aciclobeta, Aciclomed, Aciclostad, Aciclovirum, Acifar, Acihexal, Aciklovir, Acitop, Acivir, Acivirex, Acivision, Acix, Actios, Activir, Acycloguanosine, Acyl, Acyrax, Acyvir, Aklovir, Antivir, Asiviral, Avir, Aviral, Avix, Avorax, Blistex, Cicloferon, Cicloviral, Clinovir, Clirbest, Clopes, Clovate, Clovir, Cusiviral, Cyclomed, Cyclovax, Cyclovex, Cyclovir, Danovir, Declovir, Epsin, Eurovir, Hascovir, Hernovir, Herperax, Herpesil, Herpesin, Herpex, Herpin, Herplex, Heviran, Immunovir, Lisovyr, Lovir, Lovire, Lovrak, Medovir, Menova, Ocuvir, Poviral, Ranvir, Remex, Rexan, Scanovir, Sitavig, Sophivir, Soviclor, Supraviran, Telviran, Uniplex, Vilerm, Viraban, Viralex, Viratac, Viratop, Virest, Virestat, Virex, Virless, Virolex, Viromed, Virosil, Virostatic, Virovir, Virucid, Viruderm, Virustat, Virux, Vivorax, Xiclovir, Xorox, Zevin, Ziverone, Zoral, Zorax, Zoraxin, Zovirax,

Similar Products:
Lanpro, Aviral, Novax, Elavil, Envarsus, Zoroxin, Anapsique, Fokusin, Agastin, Ketovid, Oprazole, Metrocreme, Metrolyl, Pantozol, Amyn, Blavin, Kipferon, Marevan, Cliz, Novek, Lokev, Renor, Clindoral, Topictal, Aeroxina,

hascovir 400 mg cena 2000

However, most of BODIPY dyes display short emission wavelength and small Stokes shift, which limits their applications in biosensing and bioimaging in vivo. However, 99Tc(m)-MIBI was superior to Tl-201 for small-size tumours and Tl-201 was useful for large-size tumours. Survival was only related to the addition of target therapies to chemotherapy. Autoimmune inflammatory rheumatic diseases (AIIRD), such as rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis are often complicated by infection, which results in significant morbidity and mortality. By comparison to non-transformed rabbit chondrocytes, activities of superoxide dismutase 1 and 2 (SOD) and glutathione peroxidase were increased, those of glutathione reductase, glucose-6-phosphate dehydrogenase and glutathione-S-transferase fluctuated according to passages, thymidylate synthase decreased, thymidine kinase and hypoxanthine-phosphoribosyl-transferase increased and the ratio lactate dehydrogenase B/A increased.

hascovir 400 mg forum

Bile acids are major determinants of canalicular bile secretion, and there are indications that choleretic bile acids increase bile canalicular contractions, in isolated rat hepatocytes. Cell-to-cell diffusion of procion yellow in sheep and calf Purkinje fibers. Electron beam lithography (EBL) is able to generate customized protein nanopatterns. This may be because it is a discontinuous epitope that is very sensitive to subtle changes in protein conformation. The aim of this study was to assess, in a selected population, the effects of selective decontamination of the digestive tract on colonization of the oropharynx, trachea, stomach and rectum, and on the infection rate.

hascovir 0 8 cena vs lesnar

Our study suggests that excellent visual outcomes can be achieved if an immediate lamellar recut is performed after suction loss with a femtosecond laser. In this study, a reference population was selected for the first time in accordance with the systematic criteria of Sandoval et al., and the reference limit for South Koreans was established. A subunit of SP 1 was found to have a molecular mass of 30,000 Da. Data on 18 patients treated with adjunctive tirofiban injection through a temporarily deployed Solitaire stent after failed mechanical thrombectomy were retrospectively reviewed.

hascovir 800 mg cenacle

This technique not only allows the effective transfer to an arbitrary target substrate with a high degree of freedom, but also avoids PMMA etching thereby maintaining the high quality of the transferred 2D materials with minimum contamination. Feature extraction methods utilizing both the spatial and spectral profile of MI-related signals provided the best classification results, suggesting good performance of these methods in an online MEG neurofeedback system. Predicting the timing and order of future events is an essential feature of cognition in higher life forms. Differential Diagnosis of a Left Atrial Mass after Surgical Excision of Myxoma: a Remnant or a Thrombus? We calculated MR estimates for each risk factor with endometrial cancer using an inverse-variance weighted method with SNP-endometrial cancer associations from 1287 case patients and 8273 control participants.

hascovir 400 mg forum

Effect of adjuvant endocrine and adjuvant chemoendocrine therapies on metastasis of androgen-dependent Shionogi carcinoma 115. Role of UDP-Glucuronosyltransferase 1A1 in the Metabolism and Pharmacokinetics of Silymarin Flavonolignans in Patients with HCV and NAFLD.

hascovir tabletki 400 mg

Removal of thymine dimer and psoralen monoadduct by HeLa cell-free extract and of thymine dimer by Xenopus laevis oocytes. To our knowledge, our study is the first to report that the onset of PG can herald a recurrence of a solid organ malignancy and that recurrent PG can be associated with solid organ malignancy. It is well-known that many patients will have adverse reactions such as headache and nausea after undergoing myelography, but we have often seen cases where symptoms such as lower back pain and leg pain were alleviated following myelography. A Unique Human Norovirus Lineage with a Distinct HBGA Binding Interface. Rho GTPases are key regulators of the cytoskeleton during the process of neurite outgrowth.

hascovir na opryszczke cena vs lesnar

Alignment with the joint screw proved to be reproducible for working electrodes of copper and gold. Diffuse atherosclerotic disease unmasked by invasive physiologic assessment of coronary flow In the olfactory bulb, the mRNA is expresses moderately in the mitral cells, but weakly in the periglomerular cells and internal granule cells.

hascovir 400 mg cenac

It is unique in supporting disabled people in Africa and Asia with a rights-based approach. Both hepatocellular carcinoma (HCC) and iron overload are important health problems in Africa. Plasma insulin and blood glucose concentrations were measured before and after an oral glucose load.

hascovir 400 mg cena vs lesnar

The decreasing size of semiconductor features and the increasing structural complexity of advanced devices have placed continuously greater demands on manufacturing metrology, arising both from the measurement challenges of smaller feature sizes and the growing requirement to characterize structures in more than just a single critical dimension. We report a case with a high initial index of suspicion for lung malignancy. The susceptibility of trophoblastic diseases is not associated with HLA antigens.

hascovir czy hascovir progressive insurance

Among patients receiving hemodialysis with moderate to severe secondary hyperparathyroidism, use of etelcalcetide compared with placebo resulted in greater reduction in serum PTH over 26 weeks. Digestion of aortic samples either by formic acid or trypsin has resulted significantly decreasing mechanical properties in comparison with native samples. This review looks at the benefits of research in one area: temperature control. A case of retroperitoneal extra-osseous osteogenic sarcoma is reviewed, as well as the criteria necessary for the diagnosis. This opinion article summarizes our current knowledge of blood-derived biological drug delivery therapies.

hascovir 400 mg tabletki 30 szt

An awareness of the various surgical techniques, expected postoperative appearance, and potential complications is essential for radiologists. The present study focused on elderly patients receiving stereotactic radiosurgery (SRS) for few cerebral lesions. Protection did not involve synergistic viral neutralization by antibody and cells, as shown by in vitro experiments. To establish an in vitro method to culture mesenchymal stem cells(MSCs) derived from human nasal mucosa, and explore their stemness and differentiation potential. The CURB-65 score does not predict severe pandemic influenza (H1N1) 2009 CAP or need for ICU admission.

hascovir 800 mg cena vs lesnar

Seventeen experts with recognized reputations in NH care participated in the e-Delphi panel and 12 in the webinar. Measurement of human energy expenditure, with particular reference to field studies: an historical perspective. Among patients alterations in DHEA, DHEAS and androstenedione were associated with emotional distress, anxiety, dysphoric mood, positive and activation symptoms, serum prolactin levels, but were not related to age, antipsychotic agents, and extrapyramidal side effects.

hascovir 400 mg tabletki 30 szt

It has a powerful antibacterial activity with broad antibacterial spectrum. (220)Rn mitigation can be achieved by delay chamber technique, which relies on the advantage of its short half-life. Tibial tuberosity advancement (TTA) is a promising method for the treatment of cruciate ligament rupture in dogs that usually implies the implantation of a titanium cage as bone implant. Functionally sterile honey bee workers synthesize the yolk protein vitellogenin while performing nest tasks.

hascovir 800 mg cena de navidad

Furthermore Ad-XIAP transduction dramatically reduced the number of human islets required to reverse hyperglycemia in chemically diabetic immunodeficient mice. A 2-semester course sequence integrated principles from several basic science disciplines: biochemistry, molecular biology, cellular biology, anatomy, physiology, and pathophysiology.

hascovir progressive insurance

  • acyclovir 400 mg tablet dosage
  • hascovir 400 mg ulotka
  • acyclovir dosage for suppression during pregnancy
  • hascovir tabletki 800 cena vs lesnar
  • zovirax acyclovir tablets 800mg ibuprofen
  • hascovir 400 mg forum
  • hascovir w tabletkach cena vs lesnar
  • hascovir 200 mg ulotka
  • hascovir 400 mg cenar
  • compounding acyclovir ointment coupon
  • acyclovir ointment effectiveness
  • hascovir 800 mg cena broken
  • hascovir 800 mg cena 2000
  • hascovir 200 mg cena
  • hascovir 800 mg cenacle
  • hascovir 400 mg tabletki 30 szt
  • hascovir 0 8 cena vs lesnar
  • hascovir 800 mg cena
  • hascovir 400 mg cena broken
  • hascovir 400 mg cena
  • hascovir 200 tabletki cena vs lesnar
  • hascovir cena vs lesnar
  • hascovir 400 mg cena 2000
  • pencivir oder acyclovir ointment
  • hascovir tabletki 200 mg ulotka
  • various factors modifying drug action of acyclovir
  • pomada para herpes acyclovir dose
  • hascovir progressive insurance
  • acyclovir 200 mg uso etf
  • hascovir 800 mg cena romantica
  • hascovir 400 mg cenapred
  • hascovir 400 mg cena zlata
  • hascovir 800 mg cenapred
  • hascovir tabletki dawkowanie tab
  • hascovir 800 mg cena de navidad
  • acyclovir 5% ointment 30gm to ounces
  • harga acyclovir syrup
  • buy acyclovir tablets 800mg ukc
  • hascovir 400 mg cena restaurant
  • hascovir 800 mg cena zlata
  • hascovir 800 mg cena restaurant
  • hascovir czy hascovir progressive insurance
  • hascovir tabletki 400 mg cena
  • nitroprusside drug action of acyclovir
  • hascovir tabletki 800 mg
  • hascovir 800 mg cenacolo
  • hascovir 400 mg cena romantica
  • hascovir 800 mg cena vs lesnar
  • hascovir 400 mg cenac
  • hascovir 400 mg cena vs lesnar
  • hascovir na opryszczke cena vs lesnar
  • hascovir tabletki 400 mg
  • hascovir 400 mg cena de navidad
  • hascovir 400 mg cenacle
  • hascovir tabletki apteka internetowa usa
  • 400 mg pills of acyclovir 800
  • hascovir 400 mg cenacolo
  • hascovir 800 mg cenac
  • lek hascovir cena vs lesnar
  • hascovir 800 mg cenar

hascovir tabletki dawkowanie tab

Viral infections and sensitization to aeroallergens are major factors in the exacerbation of asthma and its development during early childhood. Functional analysis of Rho GTPase activation and inhibition in a bead-based miniaturized format. Quantum and impulse noise filtering from breast mammogram images. Sedation and anesthesia care for ophthalmologic surgery during local/regional anesthesia. Treatment with DPP4i reduces the risk of cardiovascular events (particularly myocardial infarction) and all-cause mortality in patients with type 2 diabetes.

acyclovir 400 mg tablet dosage

Adolescents, both humans and rodents, exhibit a marked impairment in extinction of fear relative to younger and older groups which could be caused by a failure to efficiently recruit NMDA receptors (NMDARs) in adolescence. Effects of pregnane X receptor (NR1I2) and CYP2B6 genetic polymorphisms on the induction of bupropion hydroxylation by rifampin. Data are reported on the possible mechanism of biological effects of small doses of ionizing radiation on the human body. Implications for a transition from infant to adult feeding systems as well as the development of a somatic-cardiac linkage are discussed.

hascovir 800 mg cenacle

Singularities, odds ratios, and significance: California emergency department closures and Los Angeles. In latter group only a few viruses were seen either in infected cells or free in culture. Heavy metals and its chemical speciation in sewage sludge at different stages of processing. Genotoxic and oxidative damage induced by Helicobacter pylori in Meriones unguiculatus.

hascovir 400 mg cenac

It is assumed that the NA gene controls apical meristem cell proliferation during the transition to the reproductive phase of plant development, acting much later and independently of the genes WUS-CLV. TM-AFM and high-resolution STM results show that these hydrogen-bonded assemblies self-organize to form highly ordered domains on HOPG surfaces. Together with all publicly available historical information from biodiversity repositories, we present new data from several major herpetological surveys, including recently conducted inventories on four major mountains of northeast Mindanao, and adjacent islands of Camiguin Sur, Dinagat, and Siargao. in Nature Medicine had argued that the main cause of death in sepsis is the release from neutrophil nets of nuclear histone, highly toxic to endothelial cells and that these polycations are major and unique virulence factors.

acyclovir 400 mg tablet dosage

Electrochemical studies revealed that the Fe3O4/r-GO/GC electrode possess excellent electrocatalytic activities toward the low potential oxidation of NADH (0.05 V vs. Vaccination can reduce illness and lessen severity of infection. Insect Immunity to Entomopathogenic Nematodes and Their Mutualistic Bacteria.

acyclovir dosage for suppression during pregnancy

Transcatheter device closure of atrial septal defects: a safety review. Nasal medications, including intranasal steroids and nasal decongestants, have not been shown to improve either snoring or OSA.

compounding acyclovir ointment coupon

An appeal for semantic precision in describing developmental disorders of the nervous system. Cluster of inflammatory bowel disease in three close college friends? Echocardiographic recognition of the congenital bicuspid aortic valve. The effect of acute alcoholic intoxication on the morphofunctional properties of the peripheral blood erythrocytes The segments were microdissected from freeze-dried kidney tissue of rabbits adapted to various salt diets and exposed to large differences in endogenous and exogeneous mineralocorticoids.

acyclovir 400 mg tablet dosage

In addition, Y-BOCS scores appeared to moderate improvements in QoL over the course of all treatment conditions, such that those with higher Y-BOCS scores showed the greatest improvements in QoL over time. These results indicate that dopamine has multiple anti-inflammatory effects mediated by both beta-adrenoceptor dependent and independent mechanisms. An efficient approach for organoselenium-catalyzed regioselective C-H pyridination of 1,3-dienes to form pyridinium salts has been developed. Citalopram was stopped and resolution of symptoms occurred within 48 h of discontinuing the offending agent.

hascovir tabletki 800 mg

The incidence of pelvic and aortic lymph node involvement in endometrial carcinoma depends on both tumor differentiation grade and myometrial invasion depth. Wound infection, retained stone, and reoperations were also more frequent in group I, in 4, 2, and 5 cases. Re: Lifestyle Factors and Premature Ejaculation: Are Physical Exercise, Alcohol Consumption, and Body Mass Index Associated with Premature Ejaculation and Comorbid Erectile Problems? Sequence determinants for ECP activity were screened by prediction tools, proteolysis and peptide synthesis. Death certificate and proxy respondent information from the US 1986 and 1993 National Mortality Followback Surveys (NMFS) were used to determine whether job titles with potential occupational MF exposure were risk factors for CVD mortality and whether smoking behavior may confound the observed relationship.

hascovir tabletki 400 mg cena

The probability of death was estimated using the Seattle Heart Failure Model (SHFM) and the Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) risk calculator. ADSBET2: Automated Determination of Salt-Bridge Energy-Terms version 2. Specific inhibition of contact sensitivity in the guinea pig following tolylene diisocyanate inhalation. Ethidium bromide is included in all buffers to act as an inhibitor of DNAase activity.

acyclovir 200 mg uso etf

A 25-year-old woman received oral salazosulfapyridine, 4 g/day, for treatment of ulcerative colitis. Clinical significance of serum carcinoembryonic antigen in small cell lung cancer patients Compared to healthy individuals and those with diabetes but no kidney disease, patients with diabetic nephropathy exhibited lower frequencies of 5L-5L genotype and 5L allele of CNDP1 gene, suggesting that this allele might confer protection against development of kidney disease in this population. Updated ESC Guidelines for managing patients with suspected non-ST-elevation acute coronary syndromes. Lastly, we demonstrated the biological significance of Fam20a expression in chondrocytes by evaluating osteoarthritis-related gene expression of primary articular chondrocytes.

hascovir czy hascovir progressive insurance

Flow cytometric analysis indicated that cell numbers in G0/G1 increased along with increasing apoptotic peak and percentage. A search was performed in the database on the use of CT angiography (CTA) and MR angiography (MRA) among patients with risk factors in the last 11 years. These results demonstrate a marked difference between the turkey and the rat in their response to a PRL-stimulating neuropeptide. Basic Chromosome Number of Four in the Subfamily Panicoideae of the Gramineae. Sick and tired: how molecular regulators of human sleep schedules and duration impact immune function.

hascovir 800 mg cena zlata

The experimental group was not able to perform the tests as well as the healthy control subjects. The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages. Employment and marital status, commonly described as key turning points, were not found to be significant factors associated with desistance.

hascovir 0 8 cena vs lesnar

Normothermic tumors showed a circadian rhythm with zenith at midnight and nadir at midday. In the present study, myelin formation was examined in the human fetal, postnatal and adult hippocampal formation in Down syndrome and in age-matched controls with immunohistochemistry detecting a protein component of the myelin sheath, the myelin basic protein synthesized by oligodendroglial cells. The fragmentation pattern of at least one of these suggests it is not the previously reported 35-methylokadaic acid. Because antioxidants correct photoreceptor dysfunction in diabetes, the hypothesis that exogenous visual chromophores have antioxidant activity in the retina of diabetic mice in vivo was tested.

hascovir 400 mg cena romantica

Following the perinatal onset of receptor expression, there was a rapid increase in the number of immunoreactive neurons during the first week after birth. The present study aims to establish the frequency and intensity of bone pain episodes in adult patients with SCA in clinical steady state and to determine the correlation between different inflammatory markers, other variables including QT dispersion (QTd) and pain frequency and intensity in SCA. The Effect of Various Finish Line Configurations on the Marginal Seal and Occlusal Discrepancy of Cast Full Crowns After Cementation - An In-vitro Study.

hascovir 400 mg cenapred

Among the five candidate reference genes (GAPDH, GUSB, HMBS, SDHA, UBXN6) studied in both groups, SDHA and UBXN6 were identified as the most stable. Tube insertion time with and without OPA use was recorded in the same patients in a random order during the VFSS. Electron microscopic observations of epithelioid cell granulomas experimentally induced by prototheca in the skin of mice.

hascovir 400 mg tabletki 30 szt

A Phase 2 study that evaluated several doses and administration intervals of rivaroxaban in combination with aspirin or both aspirin and clopidogrel in patients with acute coronary syndrome found that clinically significant bleeding events occurred in patients receiving rivaroxaban 10 mg daily (the dose approved for the orthopedic indication). Dysregulation of transcription during this process may lead to several diseases including various cancers. Notwithstanding the popularity of this approach, it remains difficult to directly test these mappings, both because the map often describes only a small subset of phenotypes contributing to total fitness and because direct measures of fitness are difficult to obtain and compare to the map.

 Show Hide 
pencivir oder acyclovir ointment 2019-07-28

Our goal was to compare HALS to conventional laparotomy for pelvic masses in gynecologic patients. HBA outcome in the neat sample omeprazole medicine in pakistan tresemme was significantly correlated with embryo quality, with miscarriage rates and ongoing pregnancy rates in the fresh cycles, but not with the cumulative ongoing pregnancy rate. Normal hemoglobin values derived from the analysis of a heterogenous population The grade of cancer was as follows: pT1a (3 cases), pT2 (4 cases) and pT3 (1 case).

hascovir tabletki apteka internetowa usa 2012-08-04

Bond Strength of High-Viscosity Glass Ionomer Cements is Affected by Tubular Density and Location in Dentin? Interestingly, administration of canciones para citara colombina usa PARP inhibitors, 3-aminobenzamide or PJ34 (N-(6-oxo-5,6-dihydro-phenanthridin-2-yl)-N,N-dimethyacetamide HCl), in WT mice markedly decreased acute pancreatitis severity and pulmonary-associated injury in a larger extension than genetic deletion of PARP-1.

hascovir 800 mg cena 2013-12-29

Valorization of Pomace Powder Obtained from Native Mexican Apple (Malus avis seroplex 10 mg domestica var. The matrix metalloproteinase matrilysin (MMP-7) has been demonstrated to contribute to tumor development.

hascovir 800 mg cenacolo 2010-03-22

Biological response modifiers, such as interferon or interleukin, might well be the future therapeutic approach of a ork kristali aide mopral tablets tumour known for its resistance to chemotherapy. Rather, it is likely that differences in redox activities of cytochrome aa3 and/or in substrate use play a role in the relative insensitivity of turtle brain to O2 deprivation.

acyclovir 5% ointment 30gm to ounces 2019-05-27

Patient demographics, comorbidities, pre- and postoperative neurologic state, operative opipramol alcohol interaction with metronidazole timescales, craniectomy dimensions, and Glasgow Outcome Scale scores were analyzed. Understanding the biological contributions of RAGE during cigarette smoke-induced inflammation may provide critically important insight into the pathology of COPD. The article discusses the results of study of the effect of perfluorocarbons on the cerebral blood flow and metabolism of an intact brain and in severe graded craniocerebral injury in experiments on 25 dogs. Stroke is one of the leading causes of death and disability worldwide. Also, among Asian Americans, unlike previous research showing no sex differences for stigma, we show that male participants had greater stigma levels than did female participants.

400 mg pills of acyclovir 800 2012-12-20

might contribute to high recurrence vertisal 400 mg dosis dalsy rates after immunosuppressive therapy of AI. AsIII exposure produced a decrease in the intermediates of glycolysis and the TCA cycle while increasing ketones.

hascovir 400 mg cena zlata 2012-02-09

We demonstrate coherent beam combination between independent femtosecond Yb-fiber lasers by using the active phase locking of relative pulse timing and the carrier envelope phase based on a balanced optical cross-correlator and extracavity acoustic optical frequency shifter, respectively. Facial nerve injury: a complication of superficial temporal artery biopsy. MTDH activates TWIST1 expression indirectly by 3 doses of prednisolone for croup and side facilitating histone H3 acetylation on the TWIST1 promoter, a process mediated by the histone acetyltransferase CBP.

hascovir 0 8 cena vs lesnar 2010-01-30

To reduce the right ventricular (RV) pressure and the pressure gradient between the RV and the pulmonary artery (PA) in Tetralogy of Fallot (TOF) with small pulmonary annulus, it is inevitable to enlarge the small annulus by incising and patching from RV to PA via PA annulus. Plasma Free flagyl forte metronidazole obat untuk apa lirik Amino Acid Profiles Predict Four-Year Risk of Developing Diabetes, Metabolic Syndrome, Dyslipidemia, and Hypertension in Japanese Population. Parents of infants with neonatal abstinence syndrome (NAS) in the NICU may have questions about the long-term consequences of prenatal exposure to methadone, both asked and unasked. To screen select target genes regulated by heat shock transcription factor 1 (HSF1 ) in heat shock response from myocardium of HSF1 gene knockout mice using cDNA chip. In addition, our findings support the existence of cardiac-specific functions of dystrophin and may guide studies into early triggers of cardiac disease in Duchenne and Becker muscular dystrophies.