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Patients received one of two local anaesthetics (lidocaine injection or lidocaine spray) or no anaesthesia before intratympanic injection, and used a visual analogue scale to indicate the pain level after 5 and 45 minutes. A family of proportional- and additive-hazards models for the analysis of grouped survival data is developed. In situ hybridization of mitochondrial DNA in the heart of a patient with Kearns-Sayre syndrome and dilatative cardiomyopathy. In addition, new results from our laboratory are presented regarding the involvement of the complement factor, mannose-binding lectin, in septic shock patients. A study of case-holding in leprosy patients in Asia, based on duration of treatment, 1976-80.

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Drug-naive, but not morphine-dependent, rats preferred places paired with morphine (2 mg/kg) over unfamiliar neutral places. Facilitation from compound structure comes early in development, followed by facilitation from suffixes and prefixes later on in development. Quantifying the healthcare costs of treating severely bleeding major trauma patients: a national study for England. We also find that when RAxML is allowed to run to completion, it provides an advantage over FastTree in terms of the ML score, but does not produce substantially more accurate tree topologies.

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Ultrastructural immunogold localization of tumor necrosis factor-alpha to the matrix compartment of eosinophil secondary granules in patients with idiopathic hypereosinophilic syndrome. However, reciprocally beneficial interactions that involve introduced species also can enhance invasion success and in doing so compromise ecosystem integrity. 6 cases with complete response and 23 cases with partial response by IFN-beta, and 0 cases with complete response and 13 cases with partial response by HLBI-alpha are observed. This includes a section on the legal, ethical, and psychological aspects as seen from the point of view of various cultures. Patients with mutations that induce complete or partial factor H (FH) quantitative deficiency may be controlled by plasma infusions (PI), but plasma exchanges appear more efficient than PI in patients with mutations that result in a mutant dysfunctional FH in the circulation.

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The agonist-binding site interaction is thus likely to be mediated by hydrogen bonding and not by ionic interactions. The general lack of efficacy of sumatriptan in producing alcohol-like symptoms or a desire to drink alcohol may suggest that the 5HT1D receptor plays little role in the pathophysiology of alcoholism. Microinjection into the brain with N-methyl-D-aspartate (NMDA), a synthetic analogue of glutamate, has been used as a chemical model of perinatal hypoxic-ischemic injury.

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We report 8 cases of complete heart block (CHB) occurring in patients with rheumatoid arthritis and review 20 similar patients previously reported. However, the calcified regions should be excluded from analysis to avoid decreasing the correlation between the LAC and the amount of ECM. Adolescence is a period of significant neurobiological change that occurs as individuals transition from childhood to adulthood. Conversely, a large, multiteam collegiate study found a significantly higher rate of knee injuries among brace users, a difference that remained when controlled for position, skill, and previous injury. The importance of genetic diagnosis with respect to treatment and prognosis is discussed.

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Ig synthesis was investigated in a human Epstein-barr virus transformed pre-B-like lymphoblastoid line, Josh 4. Residents with MS were more physically disabled and had more frequent pain and a higher prevalence of pressure ulcers and depression on admission than residents without MS. The number of murine blastocysts cultured in COOK medium which expressed il-6, gpx4, gpx1, and prdx2 mRNA differed significantly compared to the in vivo group. Necropsy of golden hamsters infected with metacercariae from uneaten fish revealed adult flukes identified as Metorchis conjunctus.

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Bis-allylic hydroxylation of polyunsaturated fatty acids by hepatic monooxygenases and its relation to the enzymatic and nonenzymatic formation of conjugated hydroxy fatty acids. Once a stable dosage is achieved, annual monitoring of the thyroid-stimulating hormone (TSH) level is probably unnecessary, except in older patients. The newly recognized species is further distinguished by the relative position and length of the cirrus sac, shape of seminal receptacle, and relative size of external seminal vesicle and seminal receptacle.

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No expression of HERV-K/HTDV proviruses was detected in nongerminogenic testicular tumors. These healing responses were associated with a strong T helper 1 (Th1)-like response characterized by delayed-type hypersensitivity (DTH) responsiveness, but no elevation of serum IgE, and by the production of high levels of interferon-gamma (IFN-gamma), but no interleukin-4 (IL-4) by lymph node and spleen cells after restimulation with antigen in vitro.

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Issues of organizational context, ownership, practice, culture and identifying local champions are emerging as key challenges for the next stage of implementation. In situ XAS results demonstrate the growth mechanism of the electrodeposited V2O5 thin film and suggest that its electrochromic performance strongly depends on the local atomic structure. The expression of IP-10, RANTES, and eotaxin were decreased in IL-12p40(-/-) mice and lung IL-6 expression was increased, all compared to controls.

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In addition, following multiple exposures to citric acid, the mice either sensitized to the irritant, or learned to avoid it. During normal ageing regional blood flow and oxygen consumption appeared to increase slightly in the hypothalamus and to decrease in the whole brain in 24 persons. To the best of our knowledge, this is the first case reported in which disruption of the GCNT2 gene does not involve the C isoform.

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Mitomycin has been associated with microangiopathic hemolytic anemia and renal failure. As with percutaneous ablation of tumors in the liver, lungs, and kidneys, ablation of bone and non-visceral soft tissue tumors carries risk, primarily from collateral damage to vital structures in proximity to the target tumor.

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For antidepressants, the translation of evidence of comparative effectiveness into practice is suboptimal. Here we present the first comparative primary transcriptome analysis based on the differential RNA-seq (dRNA-seq) of four C. The risk of dysuria occurring in any pregnancy was about 12 per cent, and a small group - about 6 per cent of those who had had more than one pregnancy - reported dysuria in every pregnancy. Hepatic steatosis is the key pathological feature of NAFLD and has emerged as a metabolic disorder in which innate and adaptive arms of the immune response play a central role in disease pathogenesis.

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Adjuvant therapy of surgically treated non-small cell lung cancer This study investigated how ribbed design features, including palatal rugae, may be used to significantly improve the structural performance of a maxillary denture under load. In the latter case, the rate-limiting step of the reaction is interpreted to be the breakdown of phosphoenzyme. These experiments seem to support a conclusion that the postnatal development of intestinal brush-border enzymes and the development of thymus in infant rats are controlled by endogeneously secreted glucocorticoids. The grumose degeneration observed in the dentate nuclei of 7 cases of progressive supranuclear palsy (PSP) was studied with a panel of antibodies which included 2 neurofilaments, Tau and ubiquitin.

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Light emitting diodes based on carbon dots derived from food, beverage, and combustion wastes. Patients with BD may have reduced abilities to manage personal finances, when compared against healthy participants. Prevention of permanent neurological dysfunction is crucial for long-term survival after TAR. The mean follow-up at the time of the present analysis was 46 months.

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Understanding the economic implications of a PNPE requires further study. These analyses identified 18 miRNAs that are differentially altered in fusion-negative disease, associated with DNA CpG methylation, and implicated in aggressive and AA PCas.

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A microbiologic assay was used to measure azithromycin concentrations in serum, peritoneal fluid, synovial fluid, pulmonary epithelial lining fluid (PELF), and bronchoalveolar (BAL) cells. The study was registered on the 1th of December 2011 at ClinicalTrials ( NCT01486160 ). Our previous studies have shown that the individual suppression of glutelins, 13-kDa prolamins and globulin caused the compensative accumulation of other SSPs.

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Recovery from post-traumatic stress disorder after a flood in China: a 13-year follow-up and its prediction by degree of collective action. Further, male marmots do not avoid inbreeding: males mate with equal frequency in groups composed of both related and unrelated females and in groups composed of only female relatives. In one week, this protein inhibited the mouse IgE-specific antibodies to the soluble extract as measured by PCA in rats and was therefore called Dactylis inhibitory protein (DIP). Our analysis revealed that the minimum norm estimates showed age-related reduction of SG in the bilateral SII regions.

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The renin-stimulating effect of centrally administered PGE2 is, at least in part, dependent on beta-adrenergic receptor stimulation by increased circulating catecholamines. All patients had some form of eyelid abnormality or malposition. Clinical usefulness of ursodeoxycholic acid for Japanese patients with autoimmune hepatitis. ACA implementation will dramatically enhance insurance availability and is likely to reduce financial hardship for vulnerable cancer survivors. Despite a relatively large numbers of patients receiving risperidone in this naturalistic study, no serious side-effects were reported or identified.

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In this pilot study, we established the feasibility of a brief, simple intervention to improve blood pressure control implemented by existing primary care practice clinical support staff, and preliminary data show that it can be effective in improving blood pressure control. Single-center study of technical graft loss in 714 consecutive renal transplants. Pharmacological influences on fetal lung maturity, part V: Influencing the pulmonary DPL (dipalmitoyl lecithin) level with L-thyroxin (T4) The target animal safety of a dexamethasone-prednisolone combination was studied on 12 horses divided into two groups of six each.

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Alitretinoin is the only approved treatment for severe chronic hand eczema (CHE) refractory to potent topical corticosteroids. This study was conducted over 9 months as a multicenter descriptive and qualitative study based on a self-administered questionnaire for parents of asthmatic children, aged 2-15 years.

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We present 10-year longitudinal clinical features, MRI data, and treatment response to chelation therapy of the originally described patient with a proven homozygous mutation in SLC30A10. Cytokine expression profiles during murine contact allergy: T helper 2 cytokines are expressed irrespective of the type of contact allergen. Early detection of hearing impairment in patients with diabetes mellitus with otoacoustic emission. The human immunodeficiency virus type 1 (HIV-1) accessory protein, Vpr, interacts with several host cellular proteins including uracil DNA glycosylase-2 (UNG2) and a cullin-RING E3 ubiquitin ligase assembly (CRL4(DCAF1)).

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Analytical description of partially coherent propagation and absorption losses in x-ray planar waveguides. Using genomic data from homologous microsatellite loci of pure AC repeats in humans and chimpanzees, several models of microsatellite evolution are tested and compared using likelihood-ratio tests and the Akaike information criterion. Steam sterilization did not extend the supplemental filter life. The linear working ranges of the method for preconcentration- determination of Pramipexole in water and urine samples were found to be 0.13-1000 and 0.47-1000ngmL-1 with corresponding detection limits of 0.04 and 0.14ngmL-1, respectively.

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Results indicated that anxiety did not impair comprehension, but increased word-reading times, which were affected interactively by anxiety and specific psycholinguistic variables (end of clause, serial position within the text, narrativity, and summary). Botulinum toxin (BTX is currently a recognised treatment for local spasticity, especially in children with cerebral palsy.

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This analysis, applied to measurements made in the ascending aorta of man, shows that forward running wavelets dominate during both the acceleration and deceleration phases of blood flow in the aorta. Thermodynamics studies indicated that the adsorption of Pb(II) onto CCN-Fe3O4 was spontaneous and endothermic in nature. A single band of the PCR product (DNA) of the expected size from each strain of IBDV was visible on polyacrylamide gels stained with ethidium bromide. Thus, further studies are needed, aimed at quantifying the parameters of resistance and challenge, and characterizing the relationship between them. Independent and additive impact of blood pressure control and angiotensin II receptor blockade on renal outcomes in the irbesartan diabetic nephropathy trial: clinical implications and limitations.

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The empty root canals became slowly occupied by a maturing granulation tissue occasionally containing foci of lymphocytes. The levels of extracellular ubiquitin, but not stromal cell-derived factor-1, in BALF were significantly increased by LPS.

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Numerous studies have indicated that AGEs contribute to the pathological events leading to diabetic complications, such as age-related diseases, including nephropathy, retinopathy, vasculopathy and neuropathy. Using a dynamic posturography system (modified NeuroCom EquiTest), 16 astronauts were tested at 60, 30, and 10 days preflight and retested at 1 to 5 hours, and 8 days postflight.

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During maximal exercise, the gas exchange function of the lung is challenged because of the major cardiopulmonary changes that must occur to meet the increased metabolic demands imposed by exercise. These results demonstrated that the visco-elastic property of the articular cartilage was affected not only by the varying osmotic pressures on the internal parts of the cartilage, but also on the density of the solution surrounding the cartilage and on the different water retainability of that cartilage. We collected data from patient files, including characteristics of the recipients and donors, transplantation-related factors, post-transplantation features, causes of graft loss, and patient death. The analysis of costs of services and centres enables us to identify and compare results between different suppliers, which can be useful when we need parameters to measure efficiency. Here we report that HDAC9, another class IIa HDAC, regulates hepatic gluconeogenesis via deacetylation of a Forkhead box O (FoxO) family transcription factor, FoxO1, together with HDAC3.

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Synthesis and biological evaluation of Schiff bases and azetidinones of 1-naphthol. The 256 x 200 pixel image can be segmented as one of the inputs to the ANN. We have addressed this issue by testing the effect of the conditional loss of ERK5 in primary fibroblasts. A canine hybrid double-bundle model for study of arthroscopic ACL reconstruction. Cyclic AMP-dependent up-regulation of the taurine transporter in a human retinal pigment epithelial cell line.

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Epigastraglia with tarry stools in a middle-aged female caused by jejunal intussusception due to a hamartoma. Role of DNA breaks and ADP-ribosyl transferase activity in eukaryotic differentiation demonstrated in human lymphocytes. Olaparib: an oral PARP-1 and PARP-2 inhibitor with promising activity in ovarian cancer. Functionalized magnetic beads were used as a solid phase carrier for cytokine capturing and quantification.

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In this work, an atomic force microscope (AFM) with an integrated thermal sensor has been used to obtain the local spatial distribution of temperatures in a micromachined thermopile with submicron resolution. One way around this difficulty is to use mice infected with Trichinella spiralis which by reason of anatomical location in the host would show some correlation in antinematode activity between the test and target organisms. To investigate the longitudinal effects of wheelchair rugby (WR) training on body composition of subjects with tetraplegia. The decision to use this therapy will likely remain within the art of medicine. Cross fractures through the axostyle demonstrate more extensive interrow bridging than expected on the basis of observations of thin-sectioned material.

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Thus, gestrinone and MPA administrated in vivo showed divergent influences on steroidogenic enzyme activities in ovaries, but they did not affect the serum concentration of estradiol-17 beta. We tested the hypothesis that when one bone of the skeleton is injured, others experience an osteogenic response. Nuclear Expression of GS28 Protein: A Novel Biomarker that Predicts Worse Prognosis in Cervical Cancers.

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Preliminary steps involved the linkage of BPD-MA to a modified polyvinyl alcohol (PVA) backbone, followed by conjugation to the antibody using heterobifunctional linking technology. Benzodiazepine impairment of perirhinal cortical plasticity and recognition memory. Comparison of Ti plasmids from three different biotypes of Agrobacterium tumefaciens isolated from grapevines.

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The effects of isoflurane on canine cerebral metabolism and blood flow. Possible congenital deficiency of factor X (Sturat-Prower): a case report. Lnp only affects the abundance of three-way junctions and tubules.