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Otrivine (Azelastine)

Otrivine is an antihistamine administered in aqueous solution as a nasal spray. It exhibits histamine H1 receptor antagonist activity and is used as a racemic mixture. No difference in pharmacologic activity between its enantiomers has been observed. Otrivine HCl is used to treat seasonal allergic rhinitis (e.g., hay fever) and perennial rhinitis (including runny nose, sneezing, and nasal itching). It is also used in eyedrops to treat allergic conjunctivitis. It is considered to be a very safe drug with no serious side effects. Otrivine HCl has been known since 1980, but its first US Food and Drug Administration approval for use as a nasal spray was awarded to Meda Pharmaceuticals (Somerset, NJ) under the brand name Astepro in 2008. Since its first registration, the drug has been sold under many brand names and is now generic.

Other names for this medication:
Azelastine, Afluon, Allergodil, Astelin, Astepro, Asthafen, Azel, Azelastin, Azelastina, Azelone, Azen, Azep, Azeptin, Ketasma, Lastin, Optilast, Optivar, Otrivine, Phenergan, Rhinolast, Rinalin, Xanaes,

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The nutrient sensing protein O-GlcNAc transferase (OGT) mediates post-translational O-linked N-acetylglucosamine (GlcNAc) modification. Determining limb volume by a point-gage, water-displacement technique. The aim of this study was to estimate the prevalence of latent tuberculosis (TB) infection (LTBI) among TB laboratory staff in Iran, and to elucidate the risk factors associated with LTBI. The presence of microorganisms and its relation to immunoglobulin M was not observed. DNA fragmentation and CEA production in collagen gel culture of human colon carcinoma cells.

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Airway assessment by four-phase rhinomanometry in septal surgery. Phase II study of combination therapy with high-dose cisplatin, etoposide, and mitomycin in patients with advanced non-small-cell lung cancer. The mechanism of murine cytomegalovirus-induced immunosuppression was investigated by examining the roles played by lymphocytes and adherent cells derived from spleens of infected SWR/J mice.

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Compound 1 is prepared via a tripod-tripod cyclization reaction between 1,3,5-tris-bromomethyl-benzene and an aliphatic tripodal hexatosylated polyamine, followed by the reduction of the resulting bicyclic tosylamine. Evidence that LDL receptor-related protein 1 acts as an early injury detection receptor and activates c-Jun in Schwann cells. Studies of neutrophil adhesion to endothelium have revealed two classes of adhesion proteins: selectins, and the integrin/integrin receptor system. Two-photon inactivation, photoreactivation and photoprotection in yeast cells irradiated by 266 NM-laser radiation.

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It includes 10 patients with squamous and basal cell carcinomas that interested lower or upper lip. We believe that our findings move toward a more complete understanding of complex experimental nonlinear electrokinetic phenomena. One of the causes may be related to the low PRL response to suckling stimuli.

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Cross-sectional anatomy, computed tomography and magnetic resonance imaging of the thoracic region of common dolphin (Delphinus delphis) and striped dolphin (Stenella coeruleoalba). Because empirical toxicity information for aquatic species is generally lacking for pharmaceuticals, an important data source for prioritization is that generated during the mammalian drug development process. Palpable Penile Metastases: A Bizarre Presentation of Rectal Adenocarcinoma.

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