on all orders above $300.00

FREE Pills!


for free with every order



Less than in your
local pharmacy

Search by letter:


Enter coupon: (if you have one)

Tifaxin (Venlafaxine)

Tifaxin sometimes is prescribed ‘off-label’ for generalized anxiety disorder, social anxiety disorder and panic disorder, though it’s not recommended in national treatment guidance for the UK. Your doctor should discuss the reasons why they believe this is the right medication for you before you start taking it.

Other names for this medication:
Venlafaxine, Alventa, Argofan, Benolaxe, Dobupal, Efectin, Efexor, Effexor, Elafax, Faxine, Flavix, Melocin, Memomax, Mezine, Nervix, Norpilen, Senexon, Sesaren, Subelan, Tavex, Tifaxin, Trevilor, Valax, Valosine, Vandral, Velafax, Velaxin, Venax, Venex, Veniz, Venla, Venlafaxina, Venlalic, Venlax, Venlaxor, Venlift, Vensir, Viepax,

Similar Products:
Moxacin, Miorel, Penrazol, Ulceral, Zenpro, Metryl, Fenered, Prazolit, Lamez, Pepticum, Lanzoprazol, Pantac, Soviclor, Nidagyl, Prazotec, Vilitra, Trikozol, Warfarine, Orvagil, Clavulin, Ovel, Pandon, Augpen, Pantecta, Omix, Zevin, Dapoxetina, Spamilan,

tifaxin side effects

Poorly differentiated carcinomas were nearly exclusively aneuploid, with aneuploidy mostly in the tri- to tetraploid region. Clinical data, computed tomography (CT) and sonographic findings in these four cases are analyzed. Longitudinal validation of general and specific structural features of personality pathology. However, the corresponding anatomic structures have yet to be clearly elucidated. These bioinformatics predictions were validated experimentally by immunohistochemistry and are supported by the literature.

tifaxin 75 mg

Direct communication of radiology results to patients may present an opportunity to satisfy patients and reassert the importance of the physician-patient relationship in radiology. This case presentation demonstrates radiographic evidence of lesions created following cooled radiofrequency (cRF) neurotomy of the knee. To maximize response of the physiologic and psychological consequences of the disorder, more investigation is needed to replicate the apparent findings that relate the neurochemical impairment underlying CFS and fibromyalgia to the type of antidepressant mechanism. Sickle Cell Disease with Cyanotic Congenital Heart Disease: Long-Term Outcomes in 5 Children.

tifaxin 75 mg

Raised Lp(a) lipoprotein concentrations are not responsible for the association between impaired glucose tolerance and coronary artery disease. Group FEM received a continuous femoral nerve block, group FEM/SCI received a combination of a femoral and a sciatic continuous nerve block, and group PSOAS received a continuous psoas compartment block. Possible causes of hemmorrhage following tonsillectomy (with special references to weather conditions) Quantitation of the hydroxycinnamic acid derivatives and the glycosides of flavonols and flavones by UV absorbance after identification by LC-MS. This study will provide evidence on effectiveness of delivering an innovative neonatal survival kit and/or early stimulation package to pregnant women in Kwale County, Kenya.

tifaxin side effects

Intriguingly, these proteins were all involved in semiochemical sensing (odorant binding proteins), nerve signal transmission or signal decay, indicative of the series of events required to respond to an olfactory signal from dead or diseased larvae. Animal half (a4.2- and b4.2-derived) embryos did not give rise to any gelsolin-positive neurons, indicating that differentiation of ESNs requires signals from vegetal cells. Since it has a moderate to severe myelotoxic effect, a combination of vinorelbine with cisplatin, which is a weak myelotoxic drug, is ideal for the treatment of patients with advanced disease.

tifaxin side effects

It also examines the effect of other contextual factors presented in the case studies to help interpret health-financing data. The influence of progressing pregnancy on the spinal segment transfer function showed through a shifting of peaks above 20Hz. Medial elastin content was quantified with histology postmortem. Oxygen gas occurred with rather high values in the two dental gold alloys. Olfactory neurons show an extreme diversity of cell types with each cell usually expressing one member from a large family of 60 Odorant receptor (Or) genes in Drosophila.

tifaxin 75 mg

New topological descriptors, namely, the source function (SF) and electron localization function (ELF) provide additional information as regards characterization of the topology of the electron density. Unlike intramuscular injection, gene gun delivery of DNA drives a strong type 2 response.

tifaxin 75 mg

Prazosin blunts the antinatriuretic effect of circulating angiotensin II in man. Improvements in enantioselectivity and resolution were achieved by simultaneously incorporating three chiral components into the aggregate.

tifaxin side effects

We have recently demonstrated the acute and chronic modulation of DA reuptake activity and DAT stability through S-palmitoylation, the linkage of a 16-carbon palmitate group to cysteine via a thioester bond. The scenarios encompassed differences in stage-specific survival, fecundity and hatch success, number of spawning events, and life-span effect response to chronic toxic impacts. We also reinforced the spacer with a K-wire scaffold to prevent fracture of the cement mantle in the last 21 cases. Surprisingly, the envelope precursor protein Pr74 encoded by two independently isolated, allelic envelope genes behaved differently.

tifaxin side effects

Surface plasmon resonance immunosensor for histamine based on an indirect competitive immunoreaction. Surprisingly, inactivation of the cortical selector gene Lhx2 did not affect DTM expression levels, dose-response profiles, or timing in response to BMP4, although neural progenitor genes were downregulated.

tifaxin 75 mg

Vaccine strains isolated from tissue samples must be clearly distinguishable from field strains. Controlled test for predictive power of Lyapunov exponents: their inability to predict epileptic seizures. An adenovirus vector with an HBD-3 cDNA inserted downstream of the CMV promoter (ADhBD3) was created. The envelope sequences phylogenetically belonged to subtype C and the majority of them were R5 tropic. Bovine jugular vein as aortic enlargement patch in the Norwood procedure.

tifaxin side effects

98 healthy, overweight, postmenopausal women (age: 49-58 y, BMI: 25-42 kg/m2). 762 neonates admitted to six NICUs during a 28-month observational study for whom at least one serum sample was taken on admission. Characterization of newly established human osteosarcoma cell line, LM-1.

tifaxin side effects

The factors were stable at 100 degrees and to proteases but were inactivated (after reduction) by iodoacetamide, indicating that they may be thiols or disulfides. Tracing with horseradish peroxidase demonstrated qualitatively equivalent primary afferent losses in principalis, interpolaris, and caudalis. pylori in the oral cavity of individuals with periodontal disease and gastric diseases. Following patient consultation and clinical diagnosis including hypermobile joints and skin elasticity, poor wound healing and wide scar morphology, Ehlers-Danlos syndrome was confirmed in the patient. Most reports describe an end-to-end technique with or without native nephrectomy.

tifaxin side effects

Chronic primary Friedlander pneumonia: report of a case with prompt clinical and roentgen cure following streptomycin therapy. Abstracts of the Fifty-Eighth Annual Meeting of the Health Physics Society Madison, 7-11 July, 2013, Wisconsin, USA.

tifaxin 75 mg

Family medicine residency programs at the University of Alberta (U of A) and the University of Calgary (U of C) in Alberta. This review will focus on recent findings highlighting clear links to epigenetic modifications in response to dietary manipulations as well as nutritional strategies with the potential to mitigate the effects of an otherwise poor nutritional environment. Generation of ROS in response to CCK-8 stimulation in mouse pancreatic acinar cells. The visual similarity of the contemporary athletic body and that of the comic book superhero suggests that both bodies carry a similar potential for narrative story-telling, and that their attraction is bound up with this narrative potential. Undiagnosed abdominal abscess is a medical problem of substantial clinical importance.

venlafaxine 150 mg tablets

  • venlafaxine 37.5mg price
  • venlafaxine tablets for anxiety
  • venlafaxine tablets or capsules absorption
  • venlafaxine 150 mg eurofarma uruguay
  • venlafaxine withdrawal symptoms duration
  • venlafaxine 75 mg information security
  • venlafaxine retard 37.5 mg pch
  • venlafaxine side effects withdrawal from opiates
  • venlafaxine xr 75 mg and alcohol
  • venlafaxine er brand name
  • altven venlafaxine side effects
  • apo venlafaxine xr 75mg coupon
  • do venlafaxine cause weight gain
  • venlafaxine 75 mg per day sodium
  • absetzen venlafaxine symptoms of colon
  • venlafaxine side effects when stopped on a divided
  • teva venlafaxine xr 75 mg reviews
  • venlafaxine absetzen erfahrungen c
  • shock-like sensations during venlafaxine withdrawal duration
  • venlafaxine overdose
  • venlafaxine hcl er 37.5 mg cap teva 832
  • venlafaxine er 75mg cap
  • bula venlafaxine 75 mg
  • venlafaxine xr coupons
  • venlafaxine-induced hypertension during pregnancy
  • tifaxin side effects
  • venlafaxine side effects when stopped at an intersection
  • venlafaxine brand names in pakistan face
  • venlafaxine brand names in pakistan sick
  • venlafaxine 150 mg tablets
  • venlafaxine mechanism of action
  • venlafaxine 75 mg nebenwirkungen diclofenac
  • aurobindo venlafaxine er 150 mg
  • venlafaxine 37.5 mg twice a day dosage
  • venlafaxine er capsules pictures of angels
  • venlafaxine anxiety attack
  • generic venlafaxine vs effexor xr
  • ratio venlafaxine xr uses
  • effexor xr vs venlafaxine generic
  • novo venlafaxine xr side effects
  • trevilor venlafaxine erfahrungen smart
  • venlafaxine hydrochloride er 37.5
  • venlafaxine 150 mg eurofarma trabalhe
  • venlafaxine anxiety withdrawal disorder
  • venlafaxine weight gain uk daily mail
  • venlafaxine er 150 mg high
  • 37.5 mg venlafaxine xr
  • venlafaxine er 150 tablets
  • venlafaxine 150 mg eurofarma logo
  • venlafaxine extended release capsule 225mg
  • venlafaxine and alcohol abuse
  • 37.5 mg venlafaxine for depression
  • nei global venlafaxine hydrochloride
  • venlafaxine overdose ecg placement
  • venlafaxine anxiety treatment
  • side effects of novo-venlafaxine xr 37.5 mg
  • venlafaxine withdrawal symptoms how long do they last
  • venlafaxine hcl er 37.5 capsules
  • tifaxin 75 mg
  • medicine called venlafaxine
  • venlafaxine cost walgreens

tifaxin side effects

Future studies of cognitive-behavioral treatments should be condition specific, rather than include patients with different pain conditions. Register data are fully representative of the entire population with no loss to follow-up. Few participants were able to identify the boundaries between levels accurately, with several important errors where a marked level contained none of the relevant anatomical tissue. Lethal midline granuloma (peripheral T-cell lymphoma) after lymphomatoid papulosis.

tifaxin side effects

Thus the challenge is to prevent the formation of this consortium of microorganisms using a safe approach such as antimicrobial and anti-adhesive natural products. Pediatric patients at different age groups are exposed to a spectrum of radiation dose levels and associated cancer risks different from those of adults in diagnostic nuclear medicine procedures. 16S rRNA genes have a slightly faster sequence divergence than 12S rRNA and tRNA genes. Effect of dietary canola and reference oils upon serum lipids and platelet aggregation. However, this open approach for ankle fixation may be complicated by wound dehiscence and infection, especially in high-risk patients.

tifaxin 75 mg

The purpose of this study was to evaluate whether complement component C1q binding and activation of the complement cascade in the glaucomatous retina requires the presence of immunoglobulins. However, for specific resistance to parasites that are less acute than co-circulating parasites it is the short-lived hosts that are predicted to invest most. Beside reviewing the literature they emphasize the importance of early recognition and intervention and the need of an appropriate doctor-parent cooperation in this disease. Although diabetes rates may vary among different Indian tribes, diabetes has become a widespread health problem. These findings support animal models that posit a parallel model of amygdala functioning, but importantly, also modify this position to suggest integrative processing in the amygdala.

tifaxin side effects

It is concluded that the multigated MAP offers additional information about abnormalities of the LV inferior and apical regions. trans-thionate derivatives of Pt(II) and Pd(II) with water-soluble phosphane PTA and DAPTA ligands: antiproliferative activity against human ovarian cancer cell lines. Segmentation of nuclei from images of tissue sections is important for many biological and biomedical studies.

venlafaxine 37.5 mg twice a day dosage

Future directions for intrathecal pain management: a review and update from the interdisciplinary polyanalgesic consensus conference 2007. Ultrasound-trained faculty obtained three video clips with each gel type from patients at one urban ED. The ACPFT at the ED facilitated the prompt work-ups and intervention for ACS.

venlafaxine 37.5 mg twice a day dosage

In the tripartite model, anxiety is characterized by elevated levels of physiological hyperarousal (PH), depression is characterized by low levels of positive affect (PA), and negative affect (NA) or generalized emotional distress is common to both. CA-125, placental alkaline phosphatase and tissue polypeptide antigen as preoperative serum markers in ovarian carcinoma.

venlafaxine mechanism of action

The morphology of these genetically determined, anembryonic conceptuses was similar to some of the sporadic cases of anembryonic conceptuses that occurred in control crosses. entrecasteauxii, a pregnant-specific gene expression profile has evolved, allowing for the evolution of pregnancy-specific innovations in the uterus. Two kinds of multiple regression equations were obtained (the first molar was used as an independent variable in one equation and the second molar was used in the other).

venlafaxine anxiety withdrawal disorder

None of the compounds showed genotoxicity in the Bacillus subtilis rec-assay and in the Salmonella-microsome test. We here report a case of therapy-related leukemia after S-1 administration.

venlafaxine-induced hypertension during pregnancy

For this reason, some patients tend to have chronic lesions years after onset. This study is prepared to clarify whether pathologic fracture predicts a poor prognosis of patients with osteosarcoma. This bias can result in significant discrepancies in the pooled estimates of risk factors for CP. We aim to create a database of references, protocols, and raw data related to NextGen sequencing, and to find innovative ways to reduce costs related to sequencing and bioinformatics analysis.

teva venlafaxine xr 75 mg reviews

This cross-over randomized controlled clinical trial was conducted on 48 persons with type 2 diabetes. Dietary corn oil and guar gum stimulate intestinal crypt cell proliferation in rats by independent but potentially synergistic mechanisms. This study identifies for the first time alternative splicing of the CTGF gene and shows that a short CTGF splice variant associated with cell proliferation is expressed in most cases of primary CTGF-positive pre-B ALL.

venlafaxine 150 mg tablets

Using a candidate gene approach, ITPA variants rs1127354 and rs7270101 were tested using the ABI TaqMan kit. Finally, the transition of the orientation from parallel to perpendicular is observed at high shear rates. Lyophilized formulations were stable at least for 6months and readily reconstituted in aqueous media. Cellular localization of retinoic acid receptor-gamma expression in normal and neoplastic skin. Characteristics and outcome of long-stay patients in a paediatric intensive care unit in Cape Town, South Africa.

teva venlafaxine xr 75 mg reviews

However, relative high complexity and expensiveness--combined with a usability which requires further improvement--remain obstacles to the full development of the GPS technology in human applications. Recent possibilities of the prophylaxis of urinary calculi by drugs and therapy

venlafaxine hydrochloride er 37.5

It is likely that a better psychopathological characterization of patients may inform treatment selection, and result in better treatment outcome. After the initial placement of a Pipeline Embolization Device (PED), it migrated proximally to the cavernous carotid with the distal end free in the middle of the aneurysm, resulting in only partial aneurysm neck coverage. Only one session of laser irradiation and several biophysical measurements were done. Nonresolving inflammation is now considered the underpinning of several prevalent human diseases, including atherosclerosis.

bula venlafaxine 75 mg

Distrubed growth and development due to diencephalic lesions in infancy. Ultrasound and radiographic findings were then compared, and sensitivity and specificity for ultrasound were calculated. Genomic sequencing and modern computational techniques are permitting quantitative comparisons between variation in the natural world and predictions rooted in neo-Darwinian theory, revealing the shortcomings of current evolutionary theory, particularly with regard to large-scale phenomena like macroevolution. Hyaline inclusions (Pseudopsammoma bodies) in meningiomas: immunocytochemical demonstration of epithel-like secretion of secretory component and immunoglobulins A and M. Light irradiation of PCR products removed the photolabile group and released the amino and carboxyl moieties.

venlafaxine er 150 tablets

We reviewed the medical literature and other data from 1950 through 2000 to construct estimates of the condition-specific prevalence of ID over time. Our results also suggest that the DNA-binding domain of FoxO4 remains relatively mobile while bound to the 14-3-3 protein. Activation of Hageman factor by ellagic acid was also inhibited by certain constituents of eosinophils, including eosinophil peroxidase, eosinophil major basic protein and eosinophil cationic protein.

venlafaxine anxiety treatment

Correlations for carbon resonances long-range coupled to a protonated carbon in the (1)H--(13)C HMBC spectrum are transferred via the long-range (1)H--(15)N coupling pathway in the (1)H--(15)N IMPEACH spectrum to afford a much broader range of correlation possibilities in the (13)C--(15)N HMBC-IMPEACH correlation spectrum. It has an important reference value for the diagnosis of spine tuberculosis although it is a rare imaging manifestation and diagnosis was confirmed by pathology after the surgery. Psychosis in Parkinson Disease: A Review of Etiology, Phenomenology, and Management. Giant cell pneumonia complicating acute lymphoblastic leukemia in remission. Resection of the rectum and total excision of the internal anal sphincter with smooth muscle plasty and colonic pouch for treatment of ultralow rectal carcinoma.

37.5 mg venlafaxine xr

Functioning scores were higher for the internal support when the internal assessments were performed first. This tumor belongs to middle grade malignant tumor and should be called clear cell odontogenic carcinoma. Systems biology has been recently applied to the characterization of the protective yellow fever vaccine YF17D and of seasonal flu vaccines. Thirteen weeks after nephrectomy, the afferent arteriole was dilated further, while the efferent arterioles became constricted. Speech therapy, although not entirely satisfactory, is helpful in most patients.

venlafaxine er 150 mg high

Expanding Payment Reform in Medicare: The Cardiology Episode-Based Payment Model. Accurate in silico prediction of miRNA targets in mRNA is a critical capability, allowing effective evaluation of the impact of variation on the creation, strengthening, weakening and destruction of miRNA binding sites.

venlafaxine hcl er 37.5 capsules

Smaller amounts of estrogen sulfotransferase activity that sulfated estradiol and estrone equally well were present at concentrations dependent on the sex of test animals. Artery wall binding peptide-poly(ethylene glycol)-grafted-poly(L-lysine)-based gene delivery to artery wall cells. In 1993, ability to perform self-care was assessed, and blood was drawn to determine plasma carotenoids (lycopene, beta carotene, alpha carotene, zeaxanthin and lutein combined, and beta cryptoxanthin) and alpha tocopherol.

venlafaxine overdose

Tumor recurrence after liver resection for intrahepatic cholangiocarcinoma is common. First, it activates complement, and second, it delays the functions of its control protein factor H on the cell surface, both known to damage the kidney. Nitric Oxide (NO) acts as an important neurotransmitter in generating the phase shifts of circadian rhythms and participates in sleep-wake processes, maintenance of vascular tone as well as signalling and regulating inflammatory processes.

aurobindo venlafaxine er 150 mg

We aim to evaluate the outcome of flexible ureterorenoscopy (F-URS) with holmium laser in treating renal diverticular stone as a minimal invasive option. New developments in antiretroviral drug therapy for HIV infection. To determine the prevalence of bacterial vaginosis (BV) and associated factors among 18-29-year-old women in 20 Peruvian cities using PREVEN project data. They produce type II collagen and abundant alkaline phosphatase.

 Show Hide 
venlafaxine overdose 2013-08-18

Because little is known about related factor with PTSD according to job stress level among firefighters, we assessed utility of the Minnesota Multiphasic Personality Inventory (MMPI) using 5-year medical surveillance. securo ivermectina pediculosis symptoms These embedded representations preserve the temporal order of the responses. Development of diabetes mellitus associated with quetiapine: A case series.

venlafaxine er 150 mg high 2010-11-22

Neural networks containing flagystatin reviews on greater numbers of immature neurons exhibited higher response specificity to spatial pattern stimulation, suggesting the improvement of the pattern separation by neurogenesis enhancement. Study of trans-trans farnesol effect on hyphae formation by Yarrowia lipolytica. Notably, DOX-LN overcame the resistance associated with cell passage and improved DOX efficacy fivefold.

apo venlafaxine xr 75mg coupon 2017-01-26

It is the main trends to study the mode of coevolution of plant and pyridostigmine bromide usp 30 mg animals mediated by plant secondary compounds. Cannabidiol attenuates OGD/R-induced damage by enhancing mitochondrial bioenergetics and modulating glucose metabolism via pentose-phosphate pathway in hippocampal neurons.

side effects of novo-venlafaxine xr 37.5 mg 2013-07-13

This is evident from decreased power in Upper alpha band (corresponding to Alpha band of traditional EEG system) which is representative band of relaxed mental state. It was revealed by spinal bone metastases which multiplied over the whole femalefil reviews on garcinia skeleton in spite of chemotherapy. Increased release into the medium of 45Ca and of hydroxyproline was observed when growth cartilage tissue was incubated in medium containing 1,25-dihydroxycholecalciferol.

bula venlafaxine 75 mg 2014-01-26

Supplementation of a probiotic mix reduced abdominal adiposity and increased antioxidant enzyme activity in a more effective way than an isolated dietary intervention. The oral direct thrombin inhibitor ximelagatran is stabilanol dose the first oral anticoagulant since the introduction of the vitamin K antagonists in the early 1940s. Combined Whole Methylome and Genomewide Association Study Implicates CNTN4 in Alcohol Use.

venlafaxine 150 mg eurofarma logo 2011-02-16

In this study, cationic amylose (CA) was synthesized by an etherification reaction. HER2 is overexpressed in a subset of PDACs, identifying them as possible candidates for a targeted therapy. Cisplatin-based chemoradiotherapy is the standard treatment for patients with locally advanced squamous cell carcinoma of the head and neck. Modeling of spatio-temporal variation in plague incidence swap trial clopidogrel tablets in Madagascar from 1980 to 2007.

venlafaxine withdrawal symptoms how long do they last 2017-01-21

We conducted a pilot randomized controlled trial in an urban setting and enrolled 64 parent-child dyads referred to EI. This study may serve as a guideline for directing future research on gene expression in chronic mitral valve disease. Percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) acyclovir 200mg capsule apo 114 surgery are effective procedures relieving symptoms and reducing the risk for new events, but psychosocial problems are frequent among these patients. CT diagnosis of right thalamic lesions was made and aspiration biopsy was performed using stereotactic system, obtaining a whole and death larvae. Brain derived neurotrophic factor moderates associations between maternal smoking during pregnancy and offspring behavioral disorders.

side effects of novo-venlafaxine xr 37.5 mg 2010-12-31

Available evidences seem to suggest increasing trend in sleep deficit among teenagers worldwide, and there is limited information on this among Nigerian teenagers. What are the needs of special populations with sleep disorders, amoxinject la drug information such as children, patients with mental impairment, psychiatric patients, and ICU patients?

venlafaxine er 75mg cap 2014-08-17

We divided them into three types according to the number and presence of conserved domains. Neural response test measurements, detection and speech awareness thresholds, Meaningful Auditory Integration Scale scores, as well as speech perception level achieved. Computational recognition of protein nizoral tablets buy online folds has been a recent research hotspot in bioinformatics and computational biology.

37.5 mg venlafaxine xr 2019-09-15

Discovery and characterization of GSK256073, a non-flushing hydroxy-carboxylic acid receptor 2 (HCA2) agonist. It could be concluded that traditional Persian medicine therapies can be effective in the treatment nizagara doses of pruritus with mild side effects. Comparative evaluation of microbial diversity and metabolite profiles in doenjang, a fermented soybean paste, during the two different industrial manufacturing processes. Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.

venlafaxine tablets for anxiety 2019-10-20

Comparative study between primary mediastinal B-cell lymphoma and non-mediastinal diffuse large B-cell lymphoma by immunoglobulin gene rearrangement and Epstein-Barr virus infection detection Hypertension is strongly related with activation of the sympathetic nervous system, stimulation of the renin-angiotensin-aldosterone system and endothelial dysfunction. A comparison between eye and epidermal chromatophore pigment migrations. Direct DNA oriphex dry syrup formulation analysis of the M, S, and Z alleles of the alpha 1-antitrypsin gene is possible when two molecular biology techniques are combined: a part of the gene is enzymatically replicated according to the pattern of the human DNA that is to be investigated. Nevus cell aggregates are occasionally found in the capsules and trabeculae of lymph nodes.