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Tinuvin (Ketoconazole)
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Ketoconazole

Tinuvin is active against Candida spp., and Cryptococcus neoformans. However, its activity is limited compared to that of fluconazole and itraconazole. Furthermore, due to its limited penetration to cerebrospinal fluid, it is clinically ineffective in meningeal cryptococcosis. Its activity against the dimorphic moulds, Histoplasma capsulatum, Blastomyces dermatitidis, Coccidioides immitis, Sporothrix schenckii, Paracoccidioides brasiliensis, and Penicillium marneffei is favorable. However, fluconazole and itraconazole are at least as effective as Tinuvin against these fungi and are safer. Thus, Tinuvin remains as an alternative second-line drug for treatment of infections due to dimorphic fungi. Tinuvin is not recommended for treatment of meningeal infections due to Histoplasma capsulatum, Blastomyces dermatitidis, and Coccidioides immitis due to its limited penetration to cerebrospinal fluid. Tinuvin is also active against Pseudallescheria boydii and is a good alternative for treatment of pseudallescheriasis. It is also effective in pityriasis versicolor. Tinuvin has practically no activity against Aspergillus spp., Fusarium spp., and zygomycetes order of fungi.

Other names for this medication:
Ketoconazole, Nizoral, Akorazol, Arcolan, Arcolane, Asquam, Biogel, Clarazole, Conazol, Daktagold, Daktarin, Dezor, Diazon, Dikoven, Eumicel, Extina, Funginoc, Fungoral, Ilgem, Kenazol, Kenazole, Ketazol, Ketokonazol, Ketolef, Ketovid, Ketozal, Liondox, Lizovag, Micoral, Micosin, Muzoral, Mycoderm, Noell, Orifungal, Oronazol, Panfungol, Perative, Phytoral, Pristinex, Tiniazol, Tinuvin, Xolegel, Yucomy, Zoloral,

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Gastroplex, Amoxinject, Abamune, Zoloder, Zoltum, Tetrax, Pantac, Fexidine, Lanzor, Muistin, Ritmenal, Barazan, Abalam, Sulprim, Alfu, Yucomy, Expansia, Ternelin, Prochlorperazine, Zeldox, Ranoxyl, Omeprol, Gastral, Winpen, Difluzol, Hosboral, Viramune, Oristal, Batacan, Fisat, Ortanol, Ciplin, Clofen, Funginoc, Finara, Neuril, Losepine, Ulcesep, Clavipen, Gabagamma, Daklinza, Cicloferon, Rindomox, Duraject, Lamal, Simox, Eumicel, Cipmox, Novitropan,

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The aim of this study was to evaluate outcomes after implantation of total hip arthroplasty for developmental dysplasia with high dislocation of the hip using conical stems combined with oblique subtrochanteric shortening osteotomy. The open-mouthed platinum microcapsules were prepared by template synthesis using polystyrene spheres, where surface-fused crystalline nanoparticles formed a capsule shell. Misdiagnosis of this condition as a metastatic tumor can be avoided by an awareness of these benign inclusions, supported by immunohistochemical staining results. A retrospective review was performed on a cohort of 825 surgical patients who underwent surgery during a 4-month period during Pacific Partnership 2010. However, the anatomic variations of the distally based thigh flaps have not been well classified.

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Shaping the pathogen response by protein kinase triggered oxidative burst. To investigate the effect of U14 vaccine transfected with the B7 gene in inducing antitumor immune response to murine cervical carcinoma in Chinese 615-strain mice. To understand the physiological mechanisms of temperature stress on the diapause larvae of rice stem borer Chilo suppressalis Walker at physiological and biochemical levels, determinations were made on the contents of water, lipid, total sugar and low molecular mass carbohydrates and the activities of SOD, POD, CAT in the larvae after series temperature stress (STS) and gradient temperature stress (GTS).

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Tumor angiogenesis as a predictor of recurrence and survival in patients with node-negative colon cancer. The paper does not attempt to serve as a comprehensive theoretical guide but instead describes one rigorous way of conducting a meta-analysis for diagnostic and prognostic markers. This paper aims to investigate the impact of price and non-price related population-wide tobacco control policies on smoking by socioeconomic group in nine European countries between 1990 and 2007.

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Volcanic eruptions contribute to climate variability, but quantifying these contributions has been limited by inconsistencies in the timing of atmospheric volcanic aerosol loading determined from ice cores and subsequent cooling from climate proxies such as tree rings. APTs, SPTs, and oral food challenge tests were performed in the cases with written informed consent. The new clip applier has a non--cross-type fulcrum that is closed at the time of clip release, with an action similar to that of a bipolar forceps or scissors.

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Silicon photonic biosensors combine high-sensitivity analysis with scalable, low-cost manufacturing, but they tend to measure only a single biomarker and provide no information about their (bio)chemical activity. A conventional partial denture was constructed over the model (control, group 1). The fluorescent probe LysoTracker Red was used to examine for the presence of acidic vesicles in cercariae and schistosomula of Schistosoma mansoni. Numerous functions have been proposed for this molecule, including protection of the epithelial cell surface, an involvement in epithelial organogenesis, and a role in tumor progression. Parents are increasingly faced with decisions about optional newborn bloodspot screening (NBS) despite no consistent policy for communicating information about such testing.

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The aim of this study was to investigate the psychosocial needs of elderly patients with genito-urinary tumors using screening questionnaires and to use such screening questionnaires for an in-patient psychosocial treatment program. Evaluating every incidentaloma for functional status and/or resecting all incidentalomas would not be cost-effective because the vast majority of incidentalomas are benign, non-functioning adenomas. The lower genetic diversity in populations in the south-eastern Cerrado biome is probably due to local climatic instability during the Quaternary. While the clinical presentation of frontotemporal dementia was described as early as the nineteenth century, recent advances in genetics have resulted in greater understanding of the pathophysiology of this disease.

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Selectivity evaluation and separation of human immunoglobulin G, Fab and Fc fragments with mixed-mode resins. To further investigate the molecular mechanisms of medullary thyroid carcinoma and discover candidates for targeted therapies, we developed a new mouse model of medullary thyroid carcinoma based on our CGRPCreER mouse line. Cross-sectional survey of 104 patients with leprosy followed in specialist reference centres in Sergipe, Brazil, between June and October 2014.

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We improved our optical recording system to record epifluorescence optical signals from the intact cerebral cortex. Optimization of real-time quantitative fluorescence PCR system in detecting cytochrome b gene of Prorocentrum donghaiense Lu Learning word meanings during reading: effects of phonological and semantic cues on children with language impairment. Young osteocytes located close to osteoblasts showed flattened, spindly shapes.

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The role of the CNR1 gene in schizophrenia: a systematic review including unpublished data. We investigated subtentorial limbic connections in twenty-one healthy humans by means of probabilistic constrained spherical deconvolution tractography. The nucleotide sequence of the DNA of the filamentous coliphage f1 has been determined.

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Organophosphate-induced delayed neuropathy (OPIDN) arises 1-3 weeks after exposure to some OP compounds all capable of remarkably inhibiting a distinct esterase called neuropathy target esterase (NTE) during a critical time period. Aberrant Lower Extremity Arterial Anatomy in Microvascular Free Fibula Flap Candidates: Management Algorithm and Case Presentations. Its in vivo efficacy was tested as a single agent and in combination with paclitaxel. To monitor the release of Hypercin from the NPs, an additional fluorescent lipophilic dye Coumarin-6 is incorporated in the NPs. The buccal and lingual bone levels coincided with the original bone relationship to the implant shoulder at the time of implant placement, with no signs of resorption.

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Surgery is a dangerous part of medicine and new technologies can represent hazard for patient safety. Hyaline protoplasmic astrocytopathy is a rare condition marked by the accumulation of various proteins in the cytoplasm of protoplasmic astrocytes. Because of the lack of suitable methods for metagenomics gene transfer detection, microorganisms from a low-complexity community acid mine drainage (AMD) with near-complete genomes were used to detect possible gene transfer events and suggest the biological significance. Glycine protects hepatocytes from injury caused by anoxia, cold ischemia and mitochondrial inhibitors, but not injury caused by calcium ionophores or oxidative stress.

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Novel integral membrane proteins have been identified as components of TJs, namely claudins and occludin. These contrasting responses of herbivores to disturbance-induced changes in seagrass help to better understand the ecological functioning of seagrass ecosystems in the face of human disturbances and may have important implications regarding the resilience and conservation of these threatened ecosystems. The patients precedence: the abort of instillation CO2 in abdominal cavity, the pain is significant less, the shoulders pain is significant less. An initial characterization of human heart beta-adrenoceptors and their mediation of the positive inotropic effects of catecholamines. Surface properties of dental amalgam: roughness produced by setting reaction.

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Assessment of vasodilator therapy in patients with severe congestive heart failure: limitations of measurements of left ventricular ejection fraction and volumes. We studied the expression of HLA class I and II antigens in the colons of 10 patients with familial adenomatous polyposis (FAP), a condition which leads inevitably to colorectal cancer. Pathogenesis and treatment of multiorgan dysfunction syndrome (MODS) have been presented, basing on literature and own experience. Understanding these barriers could allow strategies to reduce their impact. In this study, we investigate the anti-inflammatory effects of biochanin A on lipopolysaccharide (LPS)-induced inflammatory response in human umbilical vein endothelial cells (HUVEC cells).

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Effect of physical forces on lung structure, function, and metabolism. Monoclonal antibody AG3.0 showed the broadest reactivity recognizing the Gag capsid protein (p24-27) and Gag precursors p38, p55, and p150 of HIV-1, HIV-2, SIVmac, and SIVagm. The impact of hemodialysis on cognitive dysfunction in patients with end-stage renal disease: a resting-state functional MRI study. Forty-seven demographic, ponaris nasal drops side effects psychosocial stressor, psychopathology, and disposition variables were statistically reviewed as correlates of length of stay in 100 consecutive discharges from a child psychiatry inpatient service (age range 4-12) in a private hospital.

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