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Topigen (Topiramate)
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Topiramate

Topigen is an anticonvulsant drug used to treat epilepsy in both children and adults. In children it is also indicated for treatment of Lennox-Gastaut syndrome (a disorder that causes seizures and developmental delays). It is also Food and Drug Administration (FDA) approved, and now most frequently prescribed for, the prevention of migraines. It has been used by psychiatrists to treat bipolar disorder, although it is not FDA approved for this purpose and such use is somewhat controversial. This drug has been investigated for use in treatment of obesity, especially to aid in the reduction of binge eating, and also as a possible treatment for alcoholism.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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In the present review, we summarize evidence regarding the involvement of gaseous molecules in ischaemic brain injury and discuss the therapeutic potential of targeting gaseous molecules. In this study, we demonstrate for the first time that human spermatozoa possess interleukin-induced gene 1 (IL4I1), an l-amino acid oxidase (LAAO) which is capable of generating ROS on exposure to aromatic amino acids in the presence of oxygen.

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DIFFERENTIAL TILTING OF THE CONTINENTAL SHELF OFF THE ATLANTIC COAST OF NORTH AMERICA. Despite our limited experience with both techniques in the treatment of recurrent pectus excavatum we believe that MIRPE should be regarded as a safe and effective technique for the redo repair in adolescent and adult patients.Key words: HMRR - MIRPE recurrent pectus excavatum. For 9 of the 12 voices, agreement among listeners was significantly (and substantially) greater for the synthesis task than for the rating scale task.

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Significant differences between SLE women and healthy controls in measures of actigraphy were not found. Based on available data in clinical studies, we should be able to determine whether the Rotterdam criteria are evidence-based criteria. Dietary habits were assessed using a food frequency questionnaire, and serum samples were obtained at baseline. A family of compounds which appear to bind reversibly to double stranded DNA without intercalation between DNA base pairs has been defined.

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Research Note: The consequences of different methods for handling missing network data in Stochastic Actor Based Models. Interventions and decision-making at the end of life: the effect of establishing the terminal illness situation. Digoxigenin as an alternative probe labeling for in situ hybridization. Sodium caprate augments the hypoglycemic effect of berberine via AMPK in inhibiting hepatic gluconeogenesis.

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Prevalence and risk factors associated with spinal pain in adolescent computer users: a systematic review. The possible complications arising from the passage of objects from outside into the urinary tract should always be taken into account in patients with an external urinary diversion. Both enzymes are considerably more sensitive to hydroxyurea during catalysis than in the noncatalytic state. Our results with two reference compounds demonstrate that both methods are sensitive to alterations in contractility induced by inotropic agents administered to rats.

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However, they are also at an increased risk of experiencing side effects. Finally, in the late time latency perceptual similarity between study and test faces modified or overruled encoding-related emotion effects in the young and retrieval-related emotion effects in both age groups, respectively. Adult social position and sick leave: the mediating effect of physical workload.

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3D-FLAIR, 3D-DIR, and 3D-T1 MRI sequences were applied to evaluate white matter (WM) and gray matter (GM) lesions and global cortical thickness (gCTh). To study the related factors of central lymph node (CLN) metastasis in papillary thyroid carcinoma (PTC),the indications and the extent of central neck dissection (CND). We suggest that activation is by an indirect mechanism involving activation of endogenous genes. Progressive myelopathy occurred in a 58-year-old white man with serologic and molecular evidence of HTLV-I infection after multiple trauma and subsequent transfusion with multiple units of banked blood products. Analysis of the causes of dysentery outbreaks in preschool classes

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For the first time, time-of-flight secondary ion mass spectrometry, high-energy secondary ion mass spectrometry, and X-ray photoelectron spectroscopy are used to target endogenous compounds in fingerprints and a method is presented for establishing their relative abundance in fingerprint residue. Folic Acid Supplementation for the Prevention of Neural Tube Defects: US Preventive Services Task Force Recommendation Statement. NMR ligand-affinity screens are vital to drug discovery, are routinely used to screen fragment-based libraries, and used to verify chemical leads from high-throughput assays and virtual screens. Overall, these results suggest that signaling through the IL-1 type 1 receptor diminishes H.

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RT-PCR analysis has shown that resistance is associated with the activation of a hsr203J-like gene, which is a molecular marker of the hypersensitive reaction in tobacco. The data indicate that these assignments may be used to assess levels of antibody to PnPs serotypes in human serum.

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While most clinical trials of RIPC during coronary interventions (PCI) suggest benefit, recent large, multicentre trials in coronary artery bypass surgery suggest a lack of efficacy. Analysis of the Molecular Evolution of the Mycobacterium Tuberculosis Drug-Resistant Gene rpoB in Asia Using a Bayesian Evolutionary Method.

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Comparison of test of infant motor performance (TIMP) item responses among children with cerebral palsy, developmental delay, and typical development. Soft Tissue Closure of Grafted Extraction Sockets in the Anterior Maxilla: A Modified Palatal Pedicle Connective Tissue Flap Technique. Distinctive time courses of microstructural changes were revealed for 11 regions of the neocortical plate. This approach has led to the identification of distinct receptor domains (or individual amino acids) predicted to play key roles in ligand binding, agonist-dependent receptor activation, and G protein coupling.

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Lumagel was as effective as vascular clamping in producing a near bloodless operative field for partial nephrectomy while maintaining flow to the uninvolved portion of the affected kidney. This in turn regulates the stability and turnover of a host of CRL-targeted proteins, some of which have established roles in DDR. This is thought to be due to oxygen consumption in the absence of a hemodynamic response. Interesting consequences of the method are that structural overlay is irrelevant, that several conformations may contribute to the overall binding pattern and that lesser pharmacological activities may be deduced from the results. Preoperative opioid strength did not adversely affect outcomes in this analysis.

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The expanded scientific roles for nutraceutical supplements will be discussed in relation to the prevention and treatment of essential hypertension with emphasis on mechanisms of action and clinical integration with drug therapy as indicated based, in part, on the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure, the European Society of Hypertension, the European Society of Cardiology, the International Society of Hypertension, the Canadian Society of Hypertension, and other hypertension guidelines. Lipoma arborescens in a patient with pseudogout on hemodialysis. This is consistent with clinical mouthfeel evaluation after different modes of brushing.

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Infrared spectroscopy combined with high pressure (pressure-tuning infrared spectroscopy) was applied to the study of paired sections of basal cell carcinomas (BCC) and normal skin from ten patients. The evaluation phase prior to donation is a crucial period in the recruitment of living kidney donors, as it ensures that donors are physically and mentally suitable for donation. Subjects learned to produce specified response durations when presented with stimulus lines varying in length and angle of orientation.

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Turning metrics included average and coefficient of variation (CV) of: (1) number of turns per hour, (2) turn angle amplitude, (3) turn duration, (4) turn mean velocity, and (5) number of steps per turn. Larvicidal activity of essential oil of Peumus boldus Molina and its ascaridole-enriched fraction against Culex quinquefasciatus.

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Influence of vascular enhancement, age and gender on pulmonary perfused blood volume quantified by dual-energy-CTPA. Evidence regarding risk assessment and optimal medical strategies will be an important aspect of vascular research in the coming years. Dried blood spot analysis for therapeutic drug monitoring of linezolid in patients with multidrug-resistant tuberculosis. Medication use in patients has to be considered as a limitation of our study. Pathophysiology, diagnosis, and treatment of paroxysmal nocturnal hemoglobinuria: a review.

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A comparison of preservative-free diclofenac and preserved diclofenac eye drops after cataract surgery in patients with diabetic retinopathy. Recent milk and dairies legislation and the provision of a safe milk supply. In this study, we further investigated the mechanisms underlying the tumor suppressive function of miR-449a in neuroblastoma. Overexpression of HMGA1 correlates with the malignant status and prognosis of breast cancer.

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The safety of laser pointers is a major public health issue since class I and II laser pointers are available worldwide and used as toys by children despite several reports cautioning such use. Higher CRP values and back pain scores and lower BASFI scores at baseline were significant predictors of a higher ASAS 20 response in patients with AS receiving etanercept but predictive value was of insufficient magnitude to determine treatment in individual patients. Nursing based on the practical life and individual patients - an observation on the 9th Congress of the Japan Nursing Association Maternal Nursing Section This study was funded by National Basic Research Program of China (973 Program) (2012CB944700), the State Key Program of National Natural Science Foundation of China (81430029), National Natural Science Foundation of China (81471428) and Thousand Talents Program (Drs Legro and Zhang H).

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Effect of juvenile hormone treatment on caste differentiation in the honeybee, Apis mellifera. Correlation between serum calcium levels and dual-phase (99m)Tc-sestamibi parathyroid scintigraphy in primary hyperparathyroidism. Next, studies requiring more samples than can be sequenced on a single sequencing run (which is increasingly common) must control for run effects by including some of the same samples in all of the sequencing runs as technical replicates.

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The clinical efficacy and safety of cepharanthin for the treatment of radiotherapy-induced leukopenia were reevaluated at multiple institutions.Clinical data of cancer patients aged over 20 years old, who received a total radiotherapy dose above 40 Gy, and who were treated with cepharanthin for more than 2 weeks between April 2007 and November 2012, were evaluated. No open reading frames for proteins greater than 20 kDa were present and a database search failed to detect significant homologies to published protein sequences.

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Fifteen patients were randomized to oral-appliance and 13 to CPAP therapy. Such probes will be particularly useful in mechanistic studies on cell cycle and cell death. Due to protease inhibitor (PI) efflux transport by P-glycoprotein (P-gp), insufficient PI concentrations result in low ongoing HIV replication in the so-called virus sanctuaries (brain and testes). Our groupwise registration algorithm has been extensively evaluated by 18 elderly brains, 16 NIREP, and 40 LONI data. Although it has long been widely accepted that dopamine receptor types D1 and D2 form GPCR heteromers in the striatum, the presence of D1-D2 receptor heteromers has been recently challenged.

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We describe a syndrome based on our experience and a review of the literature of significant neurological events after partial exchange transfusion to treat priapism in sicklemic patients. coli strain, based on the two-state TF-model with a fast-sliding search state and a recognition state enabling target detection. There are few longitudinal studies that have comprehensively examined the intima-media thickness (IMT) growth pattern and its determinants among racial population groups. Childhood obesity is a growing problem, for which multi-disciplinary interventions are needed. Functional expression of bradykinin B1 and B2 receptors in neonatal rat trigeminal ganglion neurons.

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The expert panel agreed that the new classification criteria should be applied to individuals with undifferentiated inflammatory arthritis in whom at least 1 joint is deemed by an expert assessor to be swollen, indicating definite synovitis. There is mounting evidence for an age-dependent accumulation of somatic mutations as a result of the inherent imperfection of DNA replication and repair.

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Under similar missing data assumptions, the estimates and variances from all three procedures are quite close. Shear bond strength and thermal effects on the pulp chamber were assessed at 2 laser energy levels: 2 and 5 W per square centimeter. Mode of relaxant effect of papaverine on guinea-pig taenia coli was compared with that of amytal, especially in regard to their actions on the calcium movements. This review article describes how this abnormal sodium and calcium metabolism translates into increased systemic vascular resistance through altered vasoactive responses and/or vasculature structural changes. Based on the histologic stages of rejection in the different tissues at the same point in time, it is evident that each component tissue of a limb transplant rejects over a different time period.

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KIP2 is a member of CKI family, which could inhibit proliferation by tight-binding with several cyclin-CDK complexes. To assess the evidence for diagnostic tests and therapies for transverse myelitis (TM) and make evidence-based recommendations. Replacement of W64 results in a much more drastic reduction in F-actin binding affinity without significant changes in headpiece structure or stability.

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To determine the factors associated with retreatment after laser in situ keratomileusis (LASIK) for myopic eyes in the modern LASIK era. Endochondral ossification of the neural arch occurred from a single centre of ossification within each pedicle with bony fusion of the laminae occurring by one month of age. Replacing the PDZ-interacting C-termini of DSCAM and DSCAML1 with epitope tags causes different phenotypic severity in different cell populations. We reviewed renal function after pyeloplasty (PP) in cases of prenatally diagnosed ureteropelvic junction obstruction (PDUPJO) to determine the impact of preoperative urinary tract infection (UTI) on the timing of PP.

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The extent of translocation of cPKC alpha induced by TPA was more prominent than that of nPKC delta and nPKC epsilon. Subsequently, we evaluated whether the detected alterations in expression of the various CHRNs could precede histopathological modifications during the esophageal carcinogenic processes by using receiver operating characteristic curve analysis. Developmental shifts in frequency distribution of polysomal mRNA and their posttranscriptional regulation in the sea urchin embryo. Using acute exogenous CORT injections followed by behavioral trials, we found a facilitation of social preference, but we did not find increased aggression. Levocetirizine significantly inhibited resting eosinophil adhesion to rhVCAM-1 with maximal effect at 10(-8) M with an EC(50) of 10(-9) m.

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The high prevalence of fatigue in the general population appears to be significantly associated with increased lifetime and current risk for affective, anxiety, and somatoform disorders, as well as increased utilization of medical services. Post-operative temporo-frontal and interhemispheric redistribution effects, involving contralateral homologous brain areas, are suggested to contribute to the cerebral reorganisation of language function. Effective control of LSD requires accurate and rapid laboratory techniques to confirm a tentative clinical diagnosis. Microcin B17 (McB17), the first known gyrase inhibitor of peptidic nature, is produced by ribosomal synthesis and post-translational modification of the 69-residue precursor protein by an Escherichia coli strain.

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Even if mechanisms underlying periodontal regeneration by exogenous mesenchymal stromal cells are yet to be understood, this study brought to light new data regarding periodontal pocket regeneration induced by ASCs in mice. Participants were told that they represented one of four (Study 1) or two (Study 2) forestry companies and then were asked to harvest timber from a renewable forest. Endoscopic treatment of benign esophageal strictures: a literature review. Multiple perforation of small-intestine diverticula in a patient with Ehlers-Danlos syndrome. Effects of opiates and naloxone on certain enzymes of carbohydrate metabolism in human breast carcinomas.

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The combination of PI followed by Hoechst 33342 proved to be an excellent probe to distinguish live, necrotic, early- and late-apoptotic cells. Plasma concentrations of praziquantel during the therapy of neurocysticerosis with praziquantel, in the presence of antiepileptics and dexamethasone. Moreover, we found that, like in mammals, the vast majority of the GABAergic and calbindin-immunoreactive neurons within the pallium (dorsal ventricular ridge and cortical areas) have an extracortical, subpallial origin. In some cases contemporary involvement of the central nervous system has been described (CNS). Excretion, isolation and identification of the metabolites of Bisolvon.

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Urinary markers of bone resorption, pyridinoline and deoxypyridinoline, are increased in sickle cell patients with further increments during painful crisis. Clinical characteristics of those with and without xerostomia in SS and other salivary gland dysfunctions were compared.

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Osteosynthesis with miniplates in unstable maxillo-zygomatic fractures High occurrence of HIV-positive siblings due to repeated mother-to-child transmission in Brazil. The kidney tonic IGCO well protected DM rats from testicular damage, which may be related to suppression of the AGEs-RAGE-p38 MAPK pathway. Future involvement of siblings in the lives of persons with mental illness. Burden of HIV, Syphilis, and Hepatitis B and C Among Inmates in a Prison State System in Mexico.

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The results strongly suggest that the normalized hippocampal shape of the schizophrenic group is different from the control group, most significantly as a deformation difference in the tail region. Aortic lesions in aspergillosis: histopathological study of two autopsy cases. However, studies of molecular biologic associations of these lesions are proceeding. Low levels of dispositional optimism may be considered to be a risk factor for adverse reactions to high breast cancer risk information. Methods to analyze the dynamics of calcium activity often rely on visually distinguishable features in time series data such as spikes, waves, or oscillations.

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Young Scientists Award lecture 1981: The identification of an accumulation system for diamines and polyamines into the lung and its relevance to paraquat toxicity. Restoration of sagittal and transverse plane proprioception following anatomic double-bundle ACL reconstruction.

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Why China is currently underperforming in medical innovation and what China can do about it?-Part III: social psychology and evolutionary psychology perspectives. In this report, we review a case of autologous peripheral blood stem cell transplantation in a patient with systemic amyloidosis and review special considerations in peripheral blood stem cell collection in such patients.

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It was previously reported that the two main organic components of this material are proteins and carbohydrates. The second meta-analysis and subgroup analysis were performed for evidence Levels I, II, and III. Elevated serum alpha fetoprotein levels promote pathological progression of hepatocellular carcinoma. The three LAB induced the expression of genes involved in pathogen response and inhibited the growth of tumor-like germ cells, without affecting DAF16 localization or increasing corpse cells.

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This compound is formally produced by substitution of Cl for hydrogen and hydroxylation of a neighbour ring-carbon atom. These results suggest the therapeutic potential of Acanthopanax koreanum for the treatment of stress-related neuropsychiatric disorders including anxiety disorders or major depressive disorder. The expressed protein, which was distributed between the soluble and insoluble fractions, was purified to homogeneity from both fractions using a combination of classical and affinity chromatography.

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Human vomeronasal epithelium development: An immunohistochemical overview. Late tamponade after cardiac operations is spironolactone acne side effects weight loss rare but reasonably well described. Motif analysis revealed that the DEP and RhoGAP domain was common in human DEPDCs, human HCC and the adjacent tissues that widely expressed DEPDCs.

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